大鼠肝脏给予康派特^®医用胶或泰绫^®可吸收性止血纱布的安全性比较试验  

Safety Comparative Test of Compont^®Medical Adhesive and TISTAT^®Absorbable Styptic Gauze Used in Rat Liver

作　　者：卜文 李彦郎 书惠 刘超 丛源 张然然 沈连忠 

机构地区：[1]山东欣博药物研究有限公司,山东临邑251500

出　　处：《医疗装备》2015年第11期11-16,共6页Medical Equipment

摘　　要：目的:大鼠肝脏给予康派特医用胶或泰绫可吸收性止血纱布的安全性比较。方法:手术组大鼠肝脏定量切除后,给予康派特医用胶或泰绫可吸收性止血纱布止血,空白对照组大鼠不进行手术。术后动物进行临床症状观察,体重、摄食量测定,肛温、血常规、血清生化学、脏器重量和组织病理学检查。结果:各项指标均未见与康派特医用胶和泰绫相关毒性反应;3个月组织病理学检查可见胶体被纤维结缔组织分割包裹。结论:本试验条件下,未见康派特医用胶和泰绫可吸收性止血纱布对大鼠机体有毒性作用,康派特医用胶在大鼠体内3个月开始降解。Comparing the safety of Compont medical adhesiveand TISTAT absorbable styptic gauze used in rat liver. Methods：Ratsin operation groupwere resecteda quantitativeliverandstopped blooding with Compont medical adhesive or TISTATabsorbable styptic gauze.Blank group took nothing treatment.Clinical observations, body weight, food intake, rectal temperature, blood routine, serum biochemical, organ weight and histopathological examination were performed on Postoperative animals.Results：No toxic effect was observed in all indexes related with Compont medical adhesive or TISTAT Absorbable styptic gauze.Histopathological examination after administration for 3 months showed the colloid was gradually divided by fibrous connective tissue. Conclusions：The Compont medical adhesiveand TISTAT absorbable styptic gauze were no toxic effect on the body of rats under the experimental conditions, and the Compont medical adhesivebegan to degrade in rats after 3 months.

关 键 词：康派特医用胶 泰绫可吸收性止血纱布 止血 安全性 

分 类 号：R446.1[医药卫生—诊断学]