乌司他丁在婴幼儿体外循环手术中对氧自由基的影响  

Influence by ulinastatin on oxygen free radical in infant cardiopulmonary bypass operation

作　　者：董向阳[1] 李文静[1] 翟波[1] 王鹏高[1] 陈忠建[1] 陈振良[1] 崔亚洲[1] 

机构地区：[1]郑州市儿童医院,450053

出　　处：《中国实用医药》2015年第35期25-26,共2页China Practical Medicine

摘　　要：目的研究乌司他丁(UTI)在婴幼儿体外循环(CPB)手术中对氧自由基的影响。方法 36例拟在CPB下行心内直视手术的先天性心脏病婴幼儿,随机分为两组,每组18例。乌司他丁组(UTI组)转流前经中心静脉泵入乌司他丁5000 U/kg,10 min内完成;对照组(C组)给予等量平衡液。分别于转流前和转流后从中心静脉采血检测血浆超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果 1与转流前相比,转流后C组MDA含量明显升高,而SOD明显减少(P<0.05);2组间比较,转流前两组的MDA和SOD含量变化不明显,转流后C组MDA含量明显高于UTI组,而SOD含量显著低于UTI组(P<0.05)。结论乌司他丁可抑制婴幼儿CPB手术中氧自由基的产生,从而减轻心肌缺血再灌注损伤。Objective To research influence by ulinastatin （UTI） on oxygen free radical in infant cardiopulmonary bypass （CPB） operation.Methods A total of 36 infants with congenital heart disease receiving open-heart surgery under CPB were randomly divided into two groups, with 18 cases. The ulinastatin group （group UTI） received 5000 U/kg of ulinastatin through central venous pumping in 10 min before bypass. The control group （group C） received same amount of equilibrium liquid. Plasma superoxide dismutase （SOD） and methane dicarboxylic aldehyde （MDA） in central venous blood were detected before and after bypass. Results ① Comparing with those before bypass, group C had obviously higher MDA and lower SOD after bypass （P〈0.05）. ② Differences of MDA and SOD between the two groups before bypass were not obvious. After bypass, group C and much higher MDA and lower SOD than the group UTI （P〈0.05）.Conclusion Ulinastatin can suppress oxygen free radical in infant CPB operation, so as to reduce myocardial ischemia reperfusion injury.

关 键 词：乌司他丁 体外循环 氧自由基 

分 类 号：R726.5[医药卫生—儿科]