白花蛇舌草活性成分多糖与黄酮研究进展  

Research Progress in Active Constituents of Polysaccharides and Flavones from Herba Hedyotis Diffusae

作　　者：逯双 杨培民[2] 曹广尚[2] 

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东中医药大学附属医院,山东济南250011

出　　处：《中国中医药信息杂志》2016年第3期122-125,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81274052);山东省自然科学基金(ZR2011HL043)

摘　　要：白花蛇舌草具有抗肿瘤、抗氧化、免疫调节等多种药理活性。本文通过收集整理近年来国内外相关文献,发现其发挥药效的主要活性成分多糖及黄酮具有不同程度的一致性,并对二者活性成分的药理作用、提取纯化工艺进行归纳总结。尽管迄今对白花蛇舌草黄酮和多糖药效及提取研究已取得一定成果,但多以黄酮或多糖单一成分作为研究对象,对白花蛇舌草发挥药效的机理探索尚不够深入,对其成分的提取纯化工艺指标较为单一。本文结合肠道菌群的吸收代谢、药物结构与发挥药效的关系多角度推测其作用机制,展望以多指标提取工艺进行优化,为进一步开发利用白花蛇舌草提供参考。Herba Hedyotis Diffusae has many kinds of pharmacological activities such as anti-tumor, antioxidant, immune regulation and so on. This article collected and reported the related literature at home and abroad in recent years, found that pharmacological active ingredients of Herba Hedyotis Diffusae show consistency of polysaccharides and flavonoids to varying degrees, and summarized the pharmacological effects and extraction and purification process. The author believed that, the study about Herba Hedyotis Diffusae has made relatively great achievements, but the research mainly focused on polysaccharides or flavonoids, and efficacy of Herba Hedyotis Diffusae was not in enough in-depth exploration. The indicator of extraction and purification process is relatively single. This study estimated the mechanism of Herba Hedyotis Diffusae from the aspects of absorption and metabolism of intestinal flora and relationship between medicine structure and exert efficacy, hoping to optimize the extracting processes by multiple indexes, and provided references for further exploitation and utilization of Herba Hedyotis Diffusae.

关 键 词：白花蛇舌草 多糖 黄酮 综述 

分 类 号：R285[医药卫生—中药学]