某“三甲”医院2011-2014年护肝药物使用分析  

Analysis of the Utilization of Hepato-protective Drugs in a Third Grade Class A Hospital from 2011 to 2014

作　　者：朱樱[1] 叶倩倩[1] 王萍[1] 阎敏[1] 尹桃[1] 

机构地区：[1]中南大学湘雅医院药学部,长沙410008

出　　处：《中国药房》2016年第5期594-597,共4页China Pharmacy

摘　　要：目的:了解某"三甲"医院2011-2014年护肝药物的使用情况及用药趋势,为临床合理用药提供参考。方法:采用金额排序法、用药频度(DDDs)分析法对该院2011-2014年护肝药物的DDDs、日均费用(DDC)等变化情况进行分析。结果:该院2011-2014年护肝药物注射剂销售金额及DDDs呈逐年增加趋势,口服剂型则逐年减少。2011-2014年各药品DDC排序基本一致,促进能量代谢类药物DDC较高且DDDs排序较靠前,注射用门冬氨酸鸟氨酸和注射用腺苷蛋氨酸连续4年一直居前2位。多烯磷脂酰胆碱注射液和注射用还原型谷胱甘肽价格较便宜,但DDDs偏高。除了还原型谷胱甘肽片外,其余各种护肝药物的药物利用指数(DUI)前3年之间相差不大,2014年有一定波动,DUI>1和DUI<1的护肝药物占大部分。2011-2014年,相比前一年,后一年的销售金额排序/DDDs排序的序号比接近1的药品明显减少,且逐年减少。结论:该院护肝药物存在注射剂使用过于频繁、促进能量代谢类药物过度用药的情况。多烯磷脂酰胆碱注射液和注射用还原型谷胱甘肽药费可接受水平高,可以作为临床首选,但不可过量使用。OBJECTIVE：To learn the application and tendency of hepatoprotective drugs in a third grade class A hospital during 2011-2014,and to provide reference for rational drug use. METHODS：DDDs analysis and consumption ordering method were adopted to analyze the change of DDDs,DDC and other index of hepatoprotective drugs in this hospital from 2011 to 2014. RESULTS：2011-2014,the amount and DDDs of Hepatoprotective injection in this hospital increased year by year,while oral dosage form decreased year by year. DDC order of each drug kept stable during 2011-2014;DDC and DDDs of drugs for promoting energy metabolism were all in high level,and ornithine aspartate and ademetionine always took up the first 2 places in 4 years. Polyene phosphatidylcholine and Reduced glutathione injection were cheap,but had higher DDDs. Except Glutathione tablet,DUI of other hepatoprotective drugs had no great difference in 3 years,and fluctuated in 2014;hepatoprotective drugs with DUI1 and DUI1occupied a large proportion. From 2010 to 2014,compared with previous year,the drugs with consumption sum/DDDs ratio number close to 1 reduced significantly in the next year,decreasing year by year. CONCLUSIONS：In this hospital,injections are used too frequently,and overuse of drugs for promoting energy metabolism exist. Polyene phosphatidylcholine and Reduced glutathione injection can be used as a valuable drug in the clinic,and their cost are more acceptable,but not in excess.

关 键 词：护肝药物 合理用药 药物利用指数 用药频度 日均费用 

分 类 号：R969.3[医药卫生—药理学]