我院2012-2014年抗菌药物用量与大肠埃希菌耐药率的相关性分析  

Correlation of Antibacterials Amount with Drug Resistance of Escherichia coli in Our Hospital from 2012 to 2014

作　　者：赵静[1] 马艳丽[1] 宁美英[1] 张仲[1] 杨继章[2] 

机构地区：[1]沧州市中心医院药学部,河北沧州061001 [2]河北医科大学第一医院药学部,石家庄050031

出　　处：《中国药房》2016年第5期608-612,共5页China Pharmacy

基　　金：沧州市科技技术支撑项目(No.131302041)

摘　　要：目的:研究抗菌药物用药频度(DDDs)与大肠埃希菌耐药情况的关系,为规范抗菌药物临床应用提供参考。方法:采用回顾性调查方法,计算沧州市中心医院2012-2014年大肠埃希菌每季度对11种抗菌药物的耐药率及相应的抗菌药物DDDs,并应用SPSS 13.0统计软件进行相关性分析。结果:大肠埃希菌对哌拉西林钠他唑巴坦钠、头孢哌酮钠舒巴坦钠、左氧氟沙星的耐药率呈波浪式上升趋势,对其余抗菌药物的耐药率呈波浪式下降趋势。美罗培南和亚胺培南西司他丁钠在2014年出现了耐药,耐药率由0分别上升至8.8%、9.4%,同时二者的DDDs与大肠埃希菌的耐药率有极显著性相关关系,且呈正相关(r分别为0.915、0.793,P<0.01)。此外,哌拉西林钠他唑巴坦钠的DDDs与大肠埃希菌的耐药率呈极显著正相关关系(r=0.807,P<0.01),头孢他啶的DDDs与大肠埃希菌的耐药率呈显著性负相关关系(r=-0.672,P<0.05),其他7种抗菌药物的DDDs与大肠埃希菌的耐药率相关系数均无统计学意义。结论:某些抗菌药物的DDDs与大肠埃希菌的耐药水平之间存在相关性,应加强细菌耐药监测和抗菌药物临床应用合理性管理。OBJECTIVE：To study the correlation between antibacterials amount and drug resistance of Echerichia coli,and to provide reference for clinical use of antibacterials. METHODS：Retrospective review was used to calculate DDDs of antibacterials and resistance rate of Escherichia coli to 11 kinds of antibacterials each quarter. The correlation analysis was carried out using the SPSS 13.0 statistical software. RESULTS：The resistance rates of E. coli to piperacillin/tazobactam,cefoperazone/sulbactam and levofloxacin were with upward trends,and the others showed downward trends. The resistance rates of E. coli to meropenem and imipenem/cilastatin appeared in 2014,increasing from 0 to 8.8% and 9.4%,respectively. DDDs of them were significantly correlated to drug resistance of E. coli,showing positive correlation（r=0.915,0.793,P0.01）. DDDs of piperacillin/tazobactam was significantly correlated to resistance rate of E. coli（r=0.807,P0.01）,while that of ceftazidime was negatively correlated to resistance rate of E. coli（r=-0.672,P0.05）. There was no statistical significance in resistance rate of E. coli to other 7 kinds of antibacterials. CONCLUSIONS：There are some correlations between the DDDs and resistance rates. We should strengthen the monitoring of bacterial resistance and the management of rational application of antibacterials.

关 键 词：大肠埃希菌 耐药性 抗菌药物 相关性 

分 类 号：R969.1[医药卫生—药理学] R978.1[医药卫生—药学]