呋喃妥因分子印迹电化学传感器的制备及应用  

The Preparation and Application of Nitrofurantoin Molecular-Imprinted Electrochemical Sensor Based on Glassy Carbon Electrode

作　　者：胡琪[1] 谭学才[1] 杨素平[1] 黄翠玉[1] 吴佳雯[1] 李晓宇[1] 李鹏飞[1] 余会成[1] 李小燕[1] 雷福厚 

机构地区：[1]广西民族大学化学化工学院,广西林产化学与工程重点实验室,广西高校食品安全与药物分析化学重点实验室,广西南宁530008

出　　处：《分析科学学报》2016年第1期63-66,共4页Journal of Analytical Science

基　　金：国家自然科学基金(No.21365004,21065001,21165003);广西自然科学重点基金(No.2013GXNSFDA019006);广西教育厅重点科研基金(No.2013ZD019);广西高等学校高水平创新团队及卓越学者资助计划(桂教人[2014]7号);广西民族大学研究生教育创新计划(GXUN-chx2013092)

摘　　要：以甲基丙烯酸为功能单体,呋喃妥因为模板分子,马来松香丙烯酸乙二醇酯（EGMRA）为交联剂,在玻碳电极表面制备了呋喃妥因分子印迹膜。采用循环伏安（CV）法、差分脉冲伏安（DPV）法及交流阻抗（EIS）法对印迹膜进行表征。实验表明,DPV法测定的氧化峰电流与呋喃妥因浓度在8.0×10-8~5.0×10-6 mol/L范围内呈良好的线性关系（R=0.9939）,检出限为6.5×10-8 mol/L。该传感器用于呋喃妥因肠溶片的测定,其回收率为96.6%~101.6%。A molecular imprinted electrochemical sensor has been developed for the detection of nitrofurantoin（NTF）by using NTF as the template molecule,methyl acrylic acid as the functional monomer,and ethylene glycol maleic rosinate acrylate（EGMRA）as the cross-linker.The performance of the sensor was investigated by cyclic voltammetry（CV）,differential pulse voltammetry（DPV）and electrochemical impedance spectroscopy（EIS）.A linear relationship between oxidation peak current and concentration of NTF was obtained over a range from 8.0×10-8 to 5.0×10-6 mol·L-1（r=0.9939）with a detection limit（S/N=3）of 6.5×10-8 mol·L-1.The imprinted sensor was successfully used to determine NTF in pills with recoveries ranging from 96.6%to 101.6%.

关 键 词：呋喃妥因 马来松香丙烯酸乙二醇酯 分子印迹电化学传感器 

分 类 号：O657.15[理学—分析化学]