紫外分光光度法测定ET-26盐酸盐的离解常数  

Determination of the dissociation constant of ET- 26 hydrochloride by UV

作　　者：赵志玲[1] 王裴珮 钱广生[1] 张文胜[2] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]四川大学华西医院转化神经科学中心麻醉与危重急救研究室,四川成都610041

出　　处：《华西药学杂志》2016年第1期66-68,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家科技重大专项(2014ZX09101-001)

摘　　要：目的采用紫外分光光度法测定ET-26盐酸盐的离解常数(p Ka)。方法将ET-26盐酸盐溶于系列BrittonRobinson缓冲溶液中,并选择在ET-26盐酸盐适合的波长处分别测定其吸光度并计算其p Ka值。结果 ET-26盐酸盐的p Ka值为4.14。结论所用方法操作简单易行、结果准确可靠。ET-26盐酸盐的p Ka测定结果对进一步研究ET-26盐酸盐的制剂研究及其在生物体内的吸收、分布和代谢过程具有重要的意义。OBJECTIVE To determine the dissociation constant of ET- 26 hydrochloride by UV. METHODS ET- 26 hydrochloride was dissolved in series of Britton- Robinson buffer solutions,measured at wavelengths suitable for its absorbance and its pKa value was calculated. RESULTS The pKa value of ET- 26 hydrochloride was 4. 14. CONCLUSION This method is convenient and simple and the results are accurate and reliable. The results of dissociation constant of ET- 26 hydrochloride are important for the research of its formulations and absorption,distribution and metabolic processes in vivo.

关 键 词：ET-26盐酸盐 离解常数 紫外分光光度法 测定 

分 类 号：R917[医药卫生—药物分析学]