贵州少数民族人群HBV感染家庭聚集性及影响因素分析  

Familial aggregation of hepatitis B virus infection and its influence factors in minority areas of Guizhou province

作　　者：闵定玉 黄文湧[1] 杨敬源[1] 蒋芝月[1] 汪俊华[1] 杨婷婷[1] 官志忠[2] 

机构地区：[1]贵阳医学院公共卫生学院流行病学教研室,贵州贵阳550004 [2]贵阳医学院贵州省医学分子生物学重点实验室

出　　处：《中国公共卫生》2016年第2期183-187,共5页Chinese Journal of Public Health

基　　金：科技部"十二五"国家科技支撑计划(2013BAI05B03)

摘　　要：目的了解贵州省少数民族人群乙型肝炎病毒(HBV)感染的家庭聚集性及其影响因素,为预防及控制乙型肝炎(乙肝)家庭聚集性提供策略依据。方法 2013年11—12月采用多阶段整群随机抽样方法对在贵州省少数民族地区抽取的2个县8个村共1 629名常住居民进行问卷调查,并检测乙肝血清学指标,分析HBV的家庭聚集性及其影响因素。结果贵州省少数民族地区1 629名常住居民的乙肝总感染率为50.6%,乙肝表面抗原阳性率为8.3%,HBV感染的家庭聚集率为19.58%;对家庭人口数>2人的家庭进行二项分布拟合优度检验分析结果显示,家庭人口数>2人的家庭HBV感染存在家庭聚集性(χ2=14.409,P<0.05);存在家庭聚集性的家庭中,夫妻、父子、母子、兄(姐)弟(妹)、祖孙关系的HBV感染率分别为53.3%、50.0%、48.4%、44.4%、53.4%,不同家庭成员关系HBV感染率差异无统计学意义(χ2=2.598,P=0.627);多因素非条件logistic回归分析结果显示,一起生活的人乙肝表面抗原(HBs Ag)阳性、家庭人口数较多和外出打工过是贵州省少数民族人群HBV感染家庭聚集性的危险因素,有乙肝疫苗接种史和过去1年家庭总收入较高是贵州省少数民族人群HBV感染家庭聚集性的保护因素。结论贵州省少数民族人群HBV感染存在一定的家庭聚集性,一起生活的人是否HBs Ag阳性、乙肝疫苗接种史、过去1年家庭总收入、家庭人口数和是否外出打工过是HBV感染家庭聚集性的主要影响因素。Objective To examine the familial aggregation of hepatitis B virus（ HBV） infection and its influence factors in minority areas of Guizhou province and to provide evidences for the prevention and control of HBV infection.Methods By using multistage cluster random sampling,1 629 permanent residents were recruited from eight villages of two counties in minority areas of Guizhou province and surveyed with a questionnaire and HBV serological indexe detection. Results Among the residents,the overall HBV infection rate was 50. 6%; the positive rate of hepatitis B surface antigen（ HBs Ag） was 8. 3%; and the familial aggregation rate of HBV infection was 19. 58%. The results of binomial distribution fitting revealed a trend of familial aggregation in HBV infection among the residents with the families having more than 2 members（ χ2= 14. 409,P〈0. 05）. Among the residents from the families with HBV infection aggregation,no significant difference in the HBV infection rate was observed between the family members grouped by various family relations（ 53. 3% for couple,50. 0% for father-child,48. 4% for mother-child,44. 4% for sibling,and 53. 4% for grandparent-grandchild relationship,respectively）（ χ2= 2. 598,P = 0. 627）. The results of multivariate non-conditional logistic regression analysis showed that with a HBs Ag positive family member,big family size,and history of migrant working were risk factors of HBV infection familial aggregation in minority areas,whereas,HBV vaccination history and with higher total family income in previous one year were protective factors. Conclusion Familial aggregation of HBV infection exists in minority areas of Guizhou province and the aggregation is influenced by HBs Ag positivity of family member,status of HBV vaccination,total family income in previous one year,family size,ant the history of migrant working.

关 键 词：乙肝病毒(HBV)感染 家庭聚集性 影响因素 少数民族人群 

分 类 号：R512.6[医药卫生—内科学]