Beagle犬消声模型建立及评价  

Establishment and evaluation of silencer model in Beagle dogs

作　　者：李兰芳[1] 孔丽娟[1] 梁建坤[1] 王欣丽[1] 王成[1] 周晓棉[1] 郝智慧[1] 

机构地区：[1]沈阳药科大学,辽宁沈阳110016

出　　处：《中国公共卫生》2016年第2期199-202,共4页Chinese Journal of Public Health

基　　金：辽宁省科学技术计划项目(2013408001)

摘　　要：目的建立Beagle犬消声模型并评价切断右侧喉返神经对犬生理功能影响。方法普通级健康Beagle犬12条,随机分为模型组及对照组;模型组犬麻醉后,通过外科手术切断其右侧喉返神经,分别于术后3、6个月检测犬的吠叫音量;同时,检测Beagle犬心电图、呼吸、血液生理及血液生化指标。结果术后3、6个月时,对照组与模型组犬吠叫音量分别为(41.83±4.87)、(48.62±2.19)d B(A)与(33.04±2.34)、(35.20±1.98)d B(A),模型组Beagle犬吠叫音量均低于对照组(均P<0.05);术后3、6个月时,与对照组比较,模型组Beagle犬22项血液生理指标和8项血液生化指标差异均无统计学意义(均P>0.05);术后3、6个月时,与对照组比较,模型组Beagle犬呼吸运动及心电图指标差异均无统计学意义(均P>0.05)。结论损伤单侧喉返神经可明显降低Beagle犬的吠叫音量,且术后犬的血液学、心电图、呼吸指标均无明显变化。Objective To establish silencer model in Beagle dogs and to evaluate physiological function of Beagle dogs with right recurrent laryngeal nerve amputation. Methods Twelve healthy Beagle dogs were randomly divided into a model and a control group; right recurrent laryngeal nerve amputation was performed in the dogs of the model group.Barking volume was measured for all the Beagle dogs at 3-and 6-month of the experiment and electrocardiogram,respiration function,and physiological and biochemical indicators of blood of the Beagle dogs were determined simultaneously.Results The barking volumes were 41. 83 ± 4. 87 and 48. 62 ± 2. 19 d B（ A） for the control group and 33. 04 ± 2. 34 and35. 20 ± 1. 98 d B（ A） for the model group at 3- and 6-month,with significantly lower volumes in the Beagle dogs of model group compared to those of the control group（ both P〈0. 05）. No significant differences in electrocardiogram,respiration function,22 blood physiological indicators,and 8 blood biochemical indicators were observed between the control and model groups at 3- and 6-month of the experiment（ P〉0. 05 for all）. Conclusion Unilateral recurrent laryngeal nerve amputation can significantly reduce barking volume and has no significant impacts on electrocardiogram,respiration function,and hematologic indicators in Beagle dogs.

关 键 词：喉返神经损伤 BEAGLE犬 消声模型 

分 类 号：R965.1[医药卫生—药理学]