功能磁共振成像用于脑语言区定位的研究进展  

Progress of clinical application of functional MRI in the localization of brain language area

作　　者：张楠[1] 路俊锋[1] 吴劲松[1] 

机构地区：[1]复旦大学附属华山医院神经外科,上海200040

出　　处：《中华外科杂志》2016年第2期157-160,共4页Chinese Journal of Surgery

摘　　要：脑功能区手术要求在保护神经功能的前提下最大程度切除病灶，因此，准确定位功能区尤为重要。功能磁共振成像（fMRI）技术具有使用广、易掌握、非侵袭等优势，但语言fMRI的应用还处于起步阶段。语言fMRI需根据个体情况选用相应的激活任务，包括动词产生、图片命名、词语辨识、词语产生等。fMRI定位语言区的有效性依然欠佳，可通过选用多种任务提高其灵敏度。应用静息态fMRI定位语言区和深化fMRI对汉语语言区定位的应用是该领域的重要发展方向。For surgical operation in the functional area in the brain, it＇s commonly demanded to resect the lesion to the maximal extent on the basis of preserve the normal neural function, thus the precise localization of functional area is extremely important. As for the advantages of being widely available, easy to grasp and non-invasive, the functional MRI （fMRI） has come into wide use, while the application of language fMRI is still in the initial stage. It＇s important to choose appropriate fMRI task according to the individual condition of the subject, the commonly-adopted tasks include verb generation, picture naming, word recognition, word generation, etc. However, the effectiveness of using fMRI to localize language area is not totally satisfactory, adopting multiple task is an effective approach to improve the sensitivity of this technique. The application of resting state fMRI in the localization of language area and the further research of the role of fMRI in localizing the Chinese language area are the important future directions.

关 键 词：语言 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]