乌司他丁对急诊冠脉介入治疗患者肝肾功能的保护作用  

Role of ulinastatin in protection of hepatic-renal function in patients undergoing emergency PCI

作　　者：吴剑弟[1] 梁健球[1] 李琛[1] 

机构地区：[1]广东省佛山市第二人民医院心内科,528000

出　　处：《实用医学杂志》2016年第1期118-120,共3页The Journal of Practical Medicine

基　　金：广东省心血管用药研究基金(编号:2011X32);中国医师协会阳光心血管研究基金(编号:SCRFCMDA201234)

摘　　要：目的:探讨乌司他丁对急性心肌梗死(AMI)行急诊经皮冠状动脉介入治疗(PCI)患者肝肾功能的保护作用。方法:选择急性ST抬高性心肌梗死患者104例,随机分为观察组(n=55)与对照组(n=49)。观察组在PCI术前1 h使用乌司他丁30万单位静脉滴注,术后每天30万单位静脉滴注,连续3 d:对照组用等量生理盐水替代乌司他丁。比较两组患者术前与术后72 h肝肾功能相关指标:血AST、ALT、CRE(并计算CCR)。结果:PCI后两组患者血浆AST均升高,CCR均有下降,观察组变化幅度均低于对照组(P<0.05):观察组血浆ALT术后较术前下降,对照组ALT术后则较术前有所升高,两组差异有显著性(P<0.05)。结论:急诊PCI患者使用乌司他丁可保护肝肾功能,可减少相关性肝肾损害和造影剂肾病。Objective To investigate the action of ulinastatin in protection of hepatic-renal function in patients with acute myocardial infarction（AMI） receiving emergency percutaneous coronary intervention（PCI）.Methods 104 patients with acute myocardial infarction were randomly selected and divided into a study group（n = 55） and a control group（n = 49）.The study group received intravenous ulinastatin of 300,000 units one hour before PCI,and 300,000 units daily for 3 days after the procedure;while the control group received the same amount of normal saline instead of ulinastatin before and after PCI.Levels of AST,ALT,and CRE were compared between the two groups and CCR was counted before and 72 hours after the procedure.Result Serum AST level was increased and CCR was decreased after PCI;and the change in the study group was lower than that in the control group（P〈0.05）.ALT level was declined in the study group but was elevated in the control group after the procedure,with a significant difference between the two groups（P〈0.05）.Conclusions Ulinastatin can protect hepatic-renal function in patients undergoing emergency PCI,lowering contrast-induced nephropathy and damage of liver and kidneys.

关 键 词：心肌梗死 乌司他丁 经皮冠状动脉介入治疗 肝肾功能损害 

分 类 号：R542.22[医药卫生—心血管疾病]