瑞舒伐他汀和阿托伐他汀对不稳定型心绞痛患者PCI围术期心肌损伤及炎症因子水平的影响比较  

Effect comparison between rosuvastatin and atorvastatin on the myocardial damage and levels of inflammatory factors in patients with unstable angina pectoris in perioperative period of percutaneous coronary intervention

作　　者：梁涛[1] 蒋军松[2] 

机构地区：[1]广西壮族自治区河池市人民医院心血管内科,广西河池547000 [2]广西壮族自治区河池市人民医院妇产科,广西河池547000

出　　处：《实用临床医药杂志》2016年第3期18-20,24,共4页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11524389)

摘　　要：目的对比瑞舒伐他汀与阿托伐他汀对不稳定型心绞痛(UAP)患者经皮冠状动脉介入术(PCI)围术期心肌损伤及炎症因子水平的影响。方法拟行PCI治疗的UAP患者90例,随机分为瑞舒伐他汀组及阿托伐他汀组,各45例。2组在常规治疗基础上,分别给予瑞舒伐他汀钙片与阿托伐他汀钙片,比较2组术前、术后24 h的心肌损伤情况及炎症反应情况。结果术后24 h,2组血清肌酸激酶同工酶(CK-MB)及心肌肌钙蛋白I(c Tn I)均显著升高(P<0.05或P<0.01),心型脂肪酸结合蛋白(h-FABP)水平无显著变化(P>0.05);瑞舒伐他汀组CK-MB、c Tn I水平及其高于正常值的发生率均显著低于阿托伐他汀组(P<0.05或P<0.01);2组超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)及γ-干扰素(IFN-γ)水平显著升高,阿托伐他汀组各指标均显著高于瑞舒伐他汀组(P<0.01)。结论与阿托伐他汀比较,瑞舒伐他汀对UAP患者围术期的心肌保护作用更好,可有效减轻炎症反应,降低心肌损伤指标水平。Objective To compare the effect of rosuvastatin and atorvastatin on the myocardial damage and levels of inflammatory factors in patients with unstable angina pectoris（ UAP） in perioperative period of percutaneous coronary intervention（ PCI）. Methods Ninety patients with UAP who underwent PCI were randomly divided into rosuvastatin group（ n = 45） and atorvastatin group（ n = 45）. Based on the routine treatment,both groups were respectively given rosuvastatin calcium tablets and atorvastatin calcium tablets. The conditions of myocardial damage and inflammatory reaction in both groups were compared preoperatively and 24 hours after operation. Results Twentyfour hours after operation,the levels of serum creatine kinase isoenzyme（ CK-MB） and cardiac troponin I（ c Tn I） in two groups increased significantly（ P〈0. 05 or P〈0. 01）,but the level of heart type fatty acid binding protein（ h-FABP） had no obvious change（ P〈0. 05）. The levels of CK-MB and c Tn I as well as their incidence rates of higher than the normal value in rosuvastatin group were significantly lower than those in atorvastatin group（ P〈0. 05 or P〈0. 01）. Twenty-four hours after operation,the levels of high sensitive C-reactive protein（ hs-CRP）,tumor necrosis factor-α（ TNF-α） and interferon γ（ IFN-γ） in two groups elevated significantly,but the level of each indicator in atorvastatin group was significantly higher than that in rosuvastatin group（ P〈0. 01）. Conclusion Rosuvastatin is superior to atorvastatin in myocardial protection of patients with UAP in perioperative period,and it can effectively relieve inflammation reaction and decrease the levels of myocardial damage indicators.

关 键 词：不稳定型心绞痛 瑞舒伐他汀 阿托伐他汀 心肌损伤 炎症因子 

分 类 号：R541.4[医药卫生—心血管疾病]