Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector  

作　　者：Ze-chuan Yang Yan-chun Li Fan Li Qing-rong Huang 张国 石彤非 

机构地区：[1]Institute of Materials Science and Engineering,Jilin University,Changchun 130012,China [2]State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [3]Department of Pediatric Respiratory Medicine,First Hospital of Jilin University,Changchun 130021,China [4]Food Science Department,Cook College Rutgers University,New Brunswick,NJ 08901-8520,United States

出　　处：《Chinese Journal of Polymer Science》2016年第3期280-287,共8页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.51028301 and 21174146);the Special Funds for National Basic Research Program of China(No.2009CB930100)

摘　　要：New pH-responsive saccharide hydrogels were designed and prepared using curdlan derivatives（curdlan-Bochistidine, CUR-HIS）. The CUR-HIS hydrogels possessed highly porous structures. The swelling ratios of CUR-HIS hydrogels increased with the degree of substitution of Boc-histidine groups. And the addition of 0.5 mol/L Na Cl provoked a sharp reduction of swelling ratio of CUR-HIS hydrogels. Bovine serum albumin（BSA） can be efficiently encapsulated into CUR-HIS hydrogels. Moreover, the release profiles of BSA at different p H values from CUR-HIS hydrogels were significantly different. These hydrogels showed good biocompatibility in the cytotoxicity assays. The CUR-HIS hydrogels are of great potential in biomedical applications such as protein delivery systems.New pH-responsive saccharide hydrogels were designed and prepared using curdlan derivatives（curdlan-Bochistidine, CUR-HIS）. The CUR-HIS hydrogels possessed highly porous structures. The swelling ratios of CUR-HIS hydrogels increased with the degree of substitution of Boc-histidine groups. And the addition of 0.5 mol/L Na Cl provoked a sharp reduction of swelling ratio of CUR-HIS hydrogels. Bovine serum albumin（BSA） can be efficiently encapsulated into CUR-HIS hydrogels. Moreover, the release profiles of BSA at different p H values from CUR-HIS hydrogels were significantly different. These hydrogels showed good biocompatibility in the cytotoxicity assays. The CUR-HIS hydrogels are of great potential in biomedical applications such as protein delivery systems.

关 键 词：pH-responsive Hydrogel Protein Delivery 

分 类 号：O648.17[理学—物理化学] TQ460.1[理学—化学]