氯沙坦钾对老年原发性高血压伴高尿酸血症的临床疗效及安全性评价  

Clinical efficacy and safety of losartan potassium in the treatment of aged patients with essential hypertension and hyperuricemia

作　　者：杨霈龙 王立新[2] 袁芳[1] 

机构地区：[1]河北北方学院研究生部,河北张家口075000 [2]河北北方学院附属第一医院高血压门诊,河北张家口075000

出　　处：《中国临床药理学杂志》2016年第4期300-302,共3页The Chinese Journal of Clinical Pharmacology

基　　金：河北省科技计划基金资助项目(142777111D);河北北方学院自然科学研究计划基金资助项目(ZD201415);国家"十二.五"科技支撑基金资助项目(2011BAI11B04);河北省卫生厅科研基金资助项目(20110175)

摘　　要：目的观察国产氯沙坦钾片治疗老年原发性高血压合并高尿酸血症的临床疗效和安全性。方法 80例1~2级老年原发性高血压伴高尿酸血症患者随机分为试验组和对照组,每组40例。试验组口服氯沙坦钾片50 mg·d^(-1),对照组口服坎地沙坦酯4 mg·d^(-1)。2组疗程均为8周。比较2组治疗后的临床疗效、血压和血尿酸水平,并观察2组不良反应发生情况。结果治疗后,试验组和对照组的总有效率均为95.0%,显效率分别为55.0%和57.5%,差异无统计学意义(P>0.05)。试验组和对照组治疗前后血压下降幅度分别为(19.65±12.23)/(11.80±8.21)mm Hg和(24.78±15.38)/(13.93±10.60)mm Hg,2组治疗后血压显著低于治疗前(P<0.05),但组间差异无统计学意义(P>0.05)。治疗后,试验组血尿酸水平为(435.04±53.57)μmol·L^(-1),对照组为(483.68±63.50)μmol·L^(-1),试验组显著低于对照组和治疗前(P<0.05)。试验组无不良反应发生,对照组发生头晕1例(2.5%)。2组患者治疗前后心率均无明显变化。结论国产氯沙坦钾与坎地沙坦酯对老年原发性高血压患者均具有良好的降压作用,不良反应发生率低。Objective To evaluate the clinical efficacy and safety of domestic produced losartan potassium in aged patients with essential hypertension and hyperuricemia. Methods Eighty patients diagnosed with hypertension with hyperuricemia were randomly divided into treatment group（ n = 40） and control group（ n = 40）. Patients in treatment group were given losartan potassium 50 mg·d^（-1）,and patients in control group given candesartan 4 mg · d^（-1）. The treatment lasted for 8 weeks.Clinical efficiency,serum uric acid levels and blood pressure of the two groups were measured after treatment. Results After treatment,the total effective rate was equal 95. 0% in treatment group and control group and the markedly effective rate were 55. 0% and 57. 5% respectively（ P〉0. 05）. After treatment,the reduction of systolic blood pressure（ SBP） and diastolic blood pressure（ DBP） were（ 19. 65 ± 12. 23） /（ 11. 80 ± 8. 21） mm Hg vs（ 24. 78 ± 15. 38） /（ 13. 93 ± 10. 60） mm Hg in treatment group and control group（ P〈0. 05）,there was no significant difference between the two groups（ P〉0. 05）. After treatment,the level of uric acid decreased apparently in treatment group was（ 435. 04 ± 53. 57）μmol L^（-1）,and（ 483. 68 ± 63. 50） μmol·L^（-1）in control group and treatment group was significantly lower than control group and before treatment（ P〈0. 05）. There was no adverse reaction in treatment group,1 case in control group（ 2. 5%）. There was no significant change in heart rate in two groups before and after treatment. Conclusion Domestic produced losartan potassium was proved to be a stable and effective antihypertensive medication with little adverse drug reactions.

关 键 词：氯沙坦钾 坎地沙坦酯 原发性高血压 老年 高尿酸血症 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]