阿托伐他汀联合阿仑膦酸钠治疗老年性骨质疏松的临床疗效及安全性评价  

Clinical efficacy and safety of atorvastatin combined with alendronate sodium in the treatment of senile osteoporosis

作　　者：王玮琪[1] 茹选良[1] 刘春[1] 蒋增辉[1] 

机构地区：[1]浙江医院骨科,杭州310000

出　　处：《中国临床药理学杂志》2016年第4期312-314,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价阿托伐他汀联合阿仑膦酸钠治疗老年性骨质疏松的临床疗效及安全性。方法将64例老年性骨质疏松患者随机分为对照组32例和试验组32例。对照组予以口服阿仑膦酸钠70 mg,每周一次;试验组在对照组的基础上,加用口服阿托伐他汀20 mg,每天一次。2组患者疗程均为0.5年。比较2组患者的临床疗效、不同部位的骨密度、视觉模拟评分法(VAS)评分,以及不良反应的发生情况。结果治疗后,试验组的总有效率为96.88%显著高于对照组78.13%(P<0.05)。治疗后,试验组的前臂、股骨颈、腰椎正位及股骨粗隆处骨密度均明显高于对照组(P<0.05)。治疗后,试验组的VAS评分明显高于对照组(P<0.05)。试验组的不良反应率为25.00%明显低于对照组46.88%(P<0.05)。结论阿托伐他汀联合阿仑膦酸钠治疗老年性骨质疏松的临床临床疗效确切,能有效地改善患者的骨质密度,同时还能缓解患者的疼痛,降低不良反应的发生率。Objective To evaluate the clinical efficacy and safety of atorvastatin combined with alendronate sodium in the treatment of senile osteoporosis. Methods Sixty- four cases of senile osteoporosis patients were randomly divided into control group（ n = 32） and experimental group（ n = 32）. The control group was treated with oral alendronate sodium 70 mg,once a week. The experimental group was treated with alendronate sodium 70 mg,once a week and atorvastatin 20 mg,once a day.The course of treatment for two groups was half a year. The clinical efficacy,bone density,visual analogue scale（ VAS） and adverse drug reactions were compared between the two groups. Results After treatment,total effective rate in experimental group was significantly higher than that of control group（ 96. 88% vs 78. 13%,P 0. 05）. After the treatment,the bone mineral density of the forearm,femoral neck,lumbar spine and femoral neck in the experimental group were significantly higher than those in the control group（ P 0. 05）. After the treatment,the VAS score of the experimental group was significantly higher than that of the control group（ P 0. 05）. The adverse drug reactions rate in the experimental group was 46. 88%,which was significantly lower than that in the control group（ P 0. 05）. Conclusion Atorvastatin combined withalendronate sodium has a definitive clinical efficacy for the treatment of senile osteoporosis,and it can effectively improve the patients＇ bone density. At the same time it can relieve the pain of patients and reduce the incidence of adverse drug reactions.

关 键 词：阿托伐他汀 阿仑膦酸钠 老年性骨质疏松 临床疗效 安全性 

分 类 号：R714.257[医药卫生—妇产科学] R969.4[医药卫生—临床医学]