血清生物标志物水平与脑梗死伴颈动脉斑块形成的关系  

Relationship between the serum biomarkers levels and the carotid artery plaque in atherosclerotic cerebral infarction patients

作　　者：宋爱霞[1] 宋征宇[1] 纪蓉[1] 薛茜[1] 

机构地区：[1]河北北方学院附属第一医院神经内科,张家口075000

出　　处：《中国临床药理学杂志》2016年第4期318-320,共3页The Chinese Journal of Clinical Pharmacology

基　　金：河北省卫计委医学科学研究重点课题计划基金资助项目(20150469)

摘　　要：目的观察动脉粥样硬化性脑梗死(ACI)患者血清氧化低密度脂蛋白(ox-LDL)、金属基质蛋白-9(MMP-9)、C反应蛋白(CRP)水平与颈动脉斑块之间的相关性。方法选取我院110例ACI患者作为观察组,选取同期行体检的健康人群100例作为对照组,用酶联免疫吸附试验(ELISA)法检测2组血清ox-LDL、CRP和MMP-9水平,同时对ACI患者行颈动脉超声检测。结果观察组,血清ox-LDL、CRP和MMP-9水平明显高于对照组[(261.54±24.51)vs(146.51±19.59)μg·mL^(-1);(4.54±1.21)vs(0.87±0.15)μg·mL^(-1);(139.76±41.22)vs(65.76±23.48)ng·mL^(-1),均P<0.01);ACI患者中,有斑块组患者血清ox-LDL、CRP和MMP-9水平明显高于无斑块组[(205.27±20.11)vs(162.50±19.71)μg·mL^(-1);(4.32±1.03)vs(1.21±0.10)μg·mL^(-1);(90.71±24.03)vs(71.71±23.21)ng·mL^(-1),均P<0.01),且三者呈正相关性。结论血清ox-LDL、CRP和MMP-9水平升高是ACI患者颈动脉斑块形成的独立危险因素,其可作为诊断ACI和颈动脉斑块形成的重要参考指标。Objective To investigate the association of the levels of serum oxidized low density lipoprotein（ ox- LDL）,C- reactive protein（ CRP） and matrix metalloproteinase- 9（ MMP- 9） with carotid artery plaque in atherosclerotic cerebral infarction patients. Methods One hundred- ten patients with atherosclerotic cerebral infarction（ ACI）selected as the observation group,and 100 healthy subjects as control group were selected to detect the level of serum ox- LDL,CRP and MMP- 9 by enzyme- linked immunosorbent assay and the ACI patients were measured by carotid artery ultrasound. Results The levels of serum ox- LDL,CRP,and MMP- 9 in observation group were higher than those in control group [（ 261. 54 ± 24. 51） vs（ 146. 51 ± 19. 59）μg·mL^（-1）;（ 4. 54 ±1. 21） vs（ 0. 87 ±0. 15） μg·mL^（-1）;（ 139. 76 ±41. 22）vs（ 65. 76 ± 23. 48） ng·mL^（-1）,and there was significantly different（ all P〈0. 01）. The levels of serum ox- LDL,CRP,and MMP- 9 in ACI patients with plaque were higher than those in ACI patients without plaque [（ 205. 27 ± 20. 11） vs（ 162. 50 ± 19. 71） μg·mL^（-1）;（ 4. 32 ±1. 03）vs（ 1. 21 ± 0. 10） μg·mL^（-1）;（ 90. 71 ± 24. 03） vs（ 71. 71 ± 23. 21） ng·mL^（-1）,and there was significantly different（ P〈0. 01）. Serum ox- LDL,CRP and MMP- 9 levels were the independent risk factors for the formation of carotid plaques of ACI patients,and had significantly positive correlation. Conclusion The high level of serum ox- LDL,CRP,and MMP- 9 are the independent risk factors for carotid plaques of ACI,which could be used as important reference indexes for diagnosis of the formation of carotid artery plaque on ACI patients.

关 键 词：血清氧化低密度脂蛋白 C反应蛋白 金属基质蛋白-9 颈动脉斑块形成 

分 类 号：R541.4[医药卫生—心血管疾病] P065.1[医药卫生—内科学]