辣椒碱药理作用的分子机制研究进展  

Recent advances in molecular mechanisms of capsaicin′s pharmacological effect

作　　者：王荣雁 陈朝军[1] 武世奎[1] 高丽娜[1] 周南[1] 

机构地区：[1]内蒙古医科大学药学院,呼和浩特010110

出　　处：《西北药学杂志》2016年第1期108-110,共3页Northwest Pharmaceutical Journal

摘　　要：目的对近年来辣椒碱的药理活性及其分子的作用机制进行综述,提高对辣椒碱的研究水平。方法查阅大量国内外文献,总结、提炼并阐明辣椒碱的应用前景。结果辣椒碱具有镇痛、抗癌、心血管保护以及碱脂活性作用。研究发现TRPV1受体对辣椒碱药效的发挥起到了关键作用。结论预见辣椒碱在抗癌、心血管保护方面有巨大的新药开发前景。Objective To review the recent pharmacological action and phamacokinetics researches of capsaicin both domestic and abroad.Methods Recent literatures were summarized and analyzed.Result Capsaicin has the analgesic,anti-cancer,cardiovascular protective and reducing fat effect.Recent studies found that capsaicin receptor TRPV1 plays a key role in its pharmacological effects.Conclusion It is anticipated that capsaicin has great prospects for new drugs development in anticancer and cardiovascular protection.

关 键 词：辣椒碱 抗癌 心血管保护 药理作用 

分 类 号：R965[医药卫生—药理学]