Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L.  

作　　者：Qian Shen Tingxiang Yan Xueqing Fu Kexuan Tang 

机构地区：[1]Key Laboratory of Urban Agriculture (South) Ministry of Agriculture, Plant Biotechnology Research Center, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, School of Agriculture and Biology, Shanghai Jiao Tong University

出　　处：《Science Bulletin》2016年第1期18-25,共8页科学通报（英文版）

基　　金：supported by National High Technology Research and Development Program(2011AA100605);Shanghai Key Discipline Cultivation and Construction Project(Horticulture;ZXDF150005);Shanghai Jiao Tong University Agri-Engineering Program(AF1500028)

摘　　要：Artemisinin, also known as qinghaosu, a sesquiterpene endoperoxide lactone isolated from the Chinese medicinal plant Artemisia annua L., is the most effective antimalarial drug which has saved millions of lives.Due to its great antimalarial activity and low content in wild A. annua plants, researches focused on enhancing the artemisin yield in plants became a hotspot. Several families of transcription factors have been reported to participate in regulating the biosynthesis and accumulation of artemisinin.In this review, we summarize recent investigations in these fields, with emphasis on newly identified transcription factors and their functions in artemisinin biosynthesis regulation, and provide new insight for further research.Artemisinin, also known as qinghaosu, a sesquiterpene endoperoxide lactone isolated from the Chi- nese medicinal plant Artemisia annua L., is the most effective antimalarial drug which has saved millions of lives. Due to its great antimalarial activity and low content in wild A. annua plants, researches focused on enhancing the arte- misin yield in plants became a hotspot. Several families of transcription factors have been reported to participate in regulating the biosynthesis and accumulation of artemisinin. In this review, we summarize recent investigations in these fields, with emphasis on newly identified transcription fac- tors and their functions in artemisinin biosynthesis regula- tion, and provide new insight for further research.

关 键 词：Artemisia annua L. Artemisinin  Transcription factor BIOSYNTHESIS 

分 类 号：R284.3[医药卫生—中药学]