Development of artemisinin drugs in the treatment of autoimmune diseases  

作　　者：Yanwei Wu Wei Tang Jianping Zuo 

机构地区：[1]Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

出　　处：《Science Bulletin》2016年第1期37-41,共5页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(81273524;8127352581322049);the National Basic Research Program of China(2014CB541906)

摘　　要：Artemisinin drugs are a family of sesquiterpene trioxane lactone agents originally derived from Artemisia annua L. Due to the big victory in the antimalarial battle,the 2015 Nobel Prize goes to the discoverer of artemisininbased therapy for malaria. Beyond antimalaria, artemisinin and its derivatives are also being investigated in diseases like schistosomiasis, viral infection, cancers and inflammation. Over the past decades, the anti-inflammatory and immunomodulatory effects of artemisinin drugs have been comprehensively studied. In this article, we will briefly describe the development of artemisinin drugs, especially novel artemisinin derivatives, in the treatment of autoimmune diseases.Artemisinin drugs are a family of sesquiterpene trioxane lactone agents originally derived from Artemisia annua L. Due to the big victory in the antimalarial battle, the 2015 Nobel Prize goes to the discoverer of artemisinin- based therapy for malaria. Beyond antimalaria, artemisinin and its derivatives are also being investigated in diseases like schistosomiasis, viral infection, cancers and inflam- mation. Over the past decades, the anti-inflammatory and immunomodulatory effects of artemisinin drugs have been comprehensively studied. In this article, we will briefly describe the development of artemisinin drugs, especially novel artemisinin derivatives, in the treatment of autoim- mune diseases.

关 键 词：Artemisinin - Autoimmune disease Anti-inflammatory  Immunosuppressive SM934 

分 类 号：R593.2[医药卫生—内科学]