基于HIS数据库分析注射用丹参多酚酸盐对冠心病“凝血”和“血小板”指标的影响  

Based on analysis of the impact HIS database salvianolate injection for coronary heart disease,“coagulation”indicators and "platelet" indicators

作　　者：李园[1] 谢雁鸣[1] 霍剑[2] 张辉[2] 

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]中国人民大学统计学院,北京100872

出　　处：《时珍国医国药》2016年第1期243-246,共4页Lishizhen Medicine and Materia Medica Research

基　　金：北京市科技发展项目(JJ2014-53);中央级公益性科研院所基本业务费项目(Z0406;PY1303)

摘　　要：为观察冠心病＂血瘀证＂和非＂血瘀证＂患者使用注射用丹参多酚酸盐前后其凝血指标和血小板的变化情况,了解丹参多酚酸盐对患者血小板和凝血指标可能产生的影响,本研究选取全国20家大型三甲医院的医院信息系统（HIS）数据中使用注射用丹参多酚酸盐年龄在18~80岁,纳入有中医诊断患者（1088例）为研究对象,从该人群中分别提取用药前后有两次测量了凝血酶原时间（PT）、凝血酶时间（TT）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）、血小板比积（PCT）、血小板计数（PLT）和血小板体积分布宽度（PDW）、7项理化指标的患者。根据中医辨证为冠心病＂血瘀证＂和非＂血瘀证＂将患者分为2组,利用Logistic回归分析2组用药前后七个指标的变化率。wilcoxon秩和检验结果显示,凝血酶时间和血小板比积的变化率在统计学上有明显差异（P〈0.05）,平衡61个混杂因素后,2组PCT、PLT、PDW三个血小板个指标的Logistic回归显示用药前后无明显差异。本研究未发现冠心病＂血瘀证＂和非＂血瘀证＂患者用药后三个血小板指标和凝血指标的变化率有显著差异。To observe coronary heart disease＂stasis syndrome＂and not ＂blood stasis syndrome＂patients injected with Salvia changes its coagulation and platelet polyphenols before and after acid,understand salvianolate platelets and coagulation in patients that may arise affected. This study selected 20 hospitals nationwide large- scale information systems in three hospitals（ HIS） data used in injection salvianolate the age of 18 ~ 80 years old,have included patients with TCM diagnosis（ 1088 cases） for the study,from the crowd before and after treatment were extracted twice measuring the prothrombin time（ PT）,thrombin time（ TT）,activated partial thromboplastin time（ APTT）,fibrinogen（ FIB）,platelet hematocrit（ PCT）,platelet count（ PLT） and platelet volume distribution width（ PDW）,physical and chemical indicators of seven patients. According to TCM for coronary heart disease,＂stasis syndrome＂and not＂stasis syndrome＂patients were divided into two groups,the rate of change Logistic regression analysis using the two groups before and after treatment of the seven indicators. wilcoxon rank sum test results show that there is and platelet thrombin time rate of change of the plot than in the statistically significant difference（ P〈0. 05）,the balance 61 confounding factors,the two groups PCT,PLT,PDW three indicators of platelet Logistic regression showed no significant difference before and after treatment. This study found no change in the rate of three platelets and coagulation indexes after indicators of coronary heart disease ＂ stasis syndrome＂ and not ＂blood stasis syndrome＂patient medication significant difference.

关 键 词：注射用丹参多酚酸盐 HIS 血瘀证 非血瘀证 凝血指标 血小板 

分 类 号：R285.5[医药卫生—中药学]