穴位埋线治疗肝郁脾虚型非酒精性脂肪性肝病:随机对照研究  

Non-alcoholic fatty liver disease of liver stagnation and spleen deficiency pattern treated with acupoint embedding therapy:a randomized controlled trial

作　　者：黄振[1] 宋双临[1] 谭克平[2] 楚佳梅[3] 诸晓英[2] 曾友华[3] 

机构地区：[1]杭州市第一人民医院,浙江杭州310006 [2]浙江省立同德医院 [3]杭州市中医院

出　　处：《中国针灸》2016年第2期119-123,共5页Chinese Acupuncture & Moxibustion

基　　金：浙江省中医药科技计划项目:2012ZB126

摘　　要：目的:比较穴位埋线与多烯磷酯酰胆碱胶囊治疗肝郁脾虚型非酒精性脂肪性肝病的临床疗效差异。方法:采用多中心临床试验,将180例非酒精性脂肪性肝病肝郁脾虚型患者随机分为埋线组和西药组,每组90例。在控制饮食和适量运动等一般治疗的基础上,埋线组给予穴位埋线治疗,取穴肝俞、太冲、丰隆、足三里、三阴交,7天埋线1次;西药组给予口服多烯磷酯酰胆碱胶囊(易善复,228mg/粒),2粒/次,每天3次。治疗6个月后,比较两组患者治疗前后中医证候评分、肝脏酶学及血脂水平、腹部B超的变化。结果:1中医证候评分方面,埋线组显著低于西药组(P<0.05);2肝脏酶学及血脂水平方面,埋线组血清谷丙转氨酶(ALT)和血清谷草转氨酶(AST)、总胆固醇(TC)和三酰甘油(TG)水平均比西药组显著下降(均P<0.05);3腹部B超检查方面,埋线组脂肪肝程度的改善较西药组显著(P<0.05);4临床疗效方面,埋线组总有效率为89.8%(79/88),显著高于西药组的76.7%(69/90,P<0.05)。结论:穴位埋线疗法治疗肝郁脾虚型非酒精性脂肪性肝病疗效确切,且优于口服多烯磷酯酰胆碱胶囊。Objective To compare the difference between the acupoint embedding therapy and polyene phosphatidylcholine capsules in the clinical efficacy on non-alcoholic fatty liver disease（NAFLD）of liver stagnation and spleen deficiency pattern.Methods The multi-center clinical trial was adopted and 180 cases of NAFLD of liver stagnation and spleen deficiency pattern were randomized into an embedding therapy group and a western medication group,90 cases in each one.On the basis of general treatment such as diet control and proper physical exercise,in the embedding therapy group,the acupoint embedding therapy was applied to Ganshu（BL 18）,Taichong（LR 3）,Fenglong（ST 40）,Zusanli（ST 36）and Sanyinjiao（SP 6）,once every 7days;in the western medication group,polyene phosphatidylcholine capsules（essentiale）were prescribed,228mg/capsule,2capsules each time,three times a day.In 6months of treatment,TCM syndrome score,liver enzymology,blood lipid and abdomen B-ultrasound examination were observed and compared before and after treatment between the two groups.Results 1 For TCM syndrome score,the total score in the embedding therapy group was lower significantly than that in the western medication group（P〈0.05）;2 For liver enzymology and blood lipid,the levels of serum alanine transarninase（ALT）,serum glutamic oxalacetic transaminase（AST）,total cholesterol（TC）and triacylglycerol（TG）in the embedding therapy group were reduced significantly as compared with those in the western medication group（all P〈0.05）;3 For abdomen B-ultrasound examination,the fatty liver degree in the embedding therapy group was relieved significantly as compared with that in the western medication group（P〈0.05）;4 For clinical efficacy,the total effective rate was 89.8%（79/88）in the embedding therapy group,higher significantly than 76.7%（69/90）in the western medication group（P〈0.05）.Conclusion The acupoint embedding therapy achieves the definite efficacy on NAFLD of liver stagnation and spleen

关 键 词：非酒精性脂肪性肝病 肝郁脾虚型 穴位埋线疗法 多烯磷酯酰胆碱 随机对照试验 

分 类 号：R246.1[医药卫生—针灸推拿学]