雷公藤相杀、相畏配伍后雷公藤内酯甲的研究  

Study on wilforlide A before and after compatibility according to ＆quot;conteract the toxicity of another drug＆quot;

作　　者：许坡 孟楣[2] 张静[1] 江莹[1] 唐利宇 

机构地区：[1]安徽中医药大学,安徽省合肥230031 [2]安徽中医药大学第一附属医院 国家中医药管理局中药制剂三级实验室,安徽省合肥230031

出　　处：《中国基层医药》2016年第2期166-169,I0001,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：国家科技支撑计划“新安医学民方验方筛选评价研究”项目（2012BAl26803）;安徽省科技厅重点实验室计划项目（10111406029）

摘　　要：目的：研究雷公藤配伍黄芪前后雷公藤内酯甲的成分变化，探讨其可能的理论机制。方法采用 HPLC 法对雷公藤单味药材（雷公藤组）、雷公藤配伍黄芪（雷黄配伍组）及雷公藤对照品的研究，通过雷公藤内酯甲的变化进一步验证。结果该法测得雷公藤中雷公藤内酯甲的含量为0．00324％，雷黄配伍后雷公藤内酯甲的含量为0．00184％。结论雷公藤与黄芪配伍后雷公藤内酯甲的含量降低、毒性减轻，其可能降低毒性的理论机制为相杀、相畏。Objective To discuss the synergistic mechanism of compatibility of Tripterygium Wilfordii and Astragalus,and to determine wilforlide A before and after compatibility.Methods To research Tripterygium Wilfordii single medicinal materials,Tripterygium Wilfordii compatibility of Astragalus and Tripterygium Wilfordii reference substance using the HPLC method,so as to provide further verification by the change of wilforlide A.Results The content of wilforlide A was 0.00 324% by measuring Tripterygium Wilfordii single medicinal materials.The content of wilforlide A was 0.00 184% by measuring Tripterygium Wilfordii compatibility of Astragalus.Conclusion The content of wilforlide A was decreased before and after compatibility and toxicity can be reduced.The synergistic mech-anism of the compatibility of Tripterygium Wilfordii and Astragalus is “conteract the toxicity of another drug”in posse.

关 键 词：雷公藤属 黄芪 药物配伍禁忌 

分 类 号：R289.1[医药卫生—方剂学]