NT-proBNP在严重创伤失血性休克早期目标导向治疗中的临床意义  

Clinical significance of NT-proBNP in EGDT on severe trauma and hemorrhagic shock

作　　者：曹国荣[1] 李天星[1] 李伟荣[1] 刘平[1] 李国锋[1] 潘唐超[1] 李志[1] 胡绍通[1] 黄伟生[1] 

机构地区：[1]广东医学院附属三水医院急诊科,佛山528100

出　　处：《齐齐哈尔医学院学报》2016年第2期141-143,共3页Journal of Qiqihar Medical University

基　　金：佛山市科技局攻关项目(2014AB001025)

摘　　要：目的探讨NT-proBNP在严重创伤失血性休克患者早期液体复苏中的指导意义,为临床实践提供参考。方法收住急诊ICU的严重创伤失血性休克患者150例,随机分为NT-proBNP指导组与对照组(CVP组),采用相同液体复苏方法 ,比较两组液体复苏6 h时EGDT复苏指标的达标率及复苏6 h与24 h对血流动力学指标的影响。结果复苏6 h,NT组达标率为85.3%(64/75),对照组达标率为88.0%(66/75)。两组比较差异无统计学意义(P>0.05)。患者复苏6 h、24 h后,血流动力学指标CI、CO、GEF、ITBI、GEDI两组比较差异无统计学意义(P>0.05);EVLWI两组比较,差异有统计学意义(P<0.05)。结论 NT-proBNP是一个很好的反映心脏容量负荷的预测指标,可以用于指导创伤失血性休克的早期液体复苏治疗。Objective To investigate the clinical significance of NT-proBNP in the EGDT on severe trauma and hemorrhagic shock. Methods 150 patients with severe trauma and hemorrhagic shock in EICU randomly divided into 2 groups（ n = 75） ： group NT-proBNP（ group NT）,control（ group CVP）. All used the same fluid resuscitation method. Compared the two groups of the rate of reaching the standard in 6h with EGDT,and compared the results of hemodynamic parameters in 6h or 24 h. Results Fluid resuscitation 6h,NT group success rate was 85. 3%（ 64 /75）,control group success rate was 88. 0%（ 66 /75）. Between the two groups has no statistical significance（ P〉0. 05）. Patients recovery after 6 h or 24 h,hemodynamic index CI,CO,GEF,ITBI and GEDI is similar between the two groups had no statistical significance（ P〉 0. 05）. EVLWI compared two groups,the difference was statistically significant（ P〈 0. 05）. Conclusions NT-proBNP reflects a good predictor of Cardiac load capacity,it can be used to guide the early fluid resuscitation treatment of patients with severe trauma and hemorrhagic shock.

关 键 词：NT-PROBNP CVP 失血性休克 EGDT 液体复苏 

分 类 号：R543.3[医药卫生—心血管疾病]