益气养阴中药对糖尿病肾病患者炎症因子及血管内皮因子的影响  

Effect of Yiqi Yangyin Medicine on Inflammatory Factors and Vascular Endothelial Growth Factor of Diabetic Nephropathy

作　　者：陈盛业[1] 杨凯[2] 董佳妮[3] 张兰[3] 

机构地区：[1]沈阳市第七人民医院,辽宁沈阳110000 [2]沈阳市第六人民医院,辽宁沈阳110006 [3]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中医药信息》2016年第1期46-49,共4页Information on Traditional Chinese Medicine

基　　金：辽宁省科技厅项目(No.2010225034)

摘　　要：目的:探讨益气养阴法对糖尿病肾病患者炎症因子及血管内皮因子的影响。方法:符合纳入标准的60例气阴两虚型糖尿病肾病早期患者随机分为观察组30例,对照组30例,两组均给予综合治疗措施,观察组加用益气养阴中药,对照组加用厄贝沙坦及与中药组相似的安慰剂,3个月为1个疗程,共观察6个月,观察治疗前后肿瘤坏死因子(TNF-α),白介素6(IL-6),C反应蛋白(CRP),血浆内皮素(ET),一氧化氮(NO)水平的变化,进行综合评价。结果:治疗后两组患者TNF-α、IL-6、CRP比较:与治疗前相比,两组差异均有统计学意义(P<0.05),两组组间相比差异有统计学意义(P<0.05)。治疗后两组ET、NO比较:与治疗前相比,两组差异均有统计学意义(P<0.05),两组组间相比差异有统计学意义(P<0.05)。结论:益气养阴中药治疗糖尿病肾病可降低机体炎症因子水平,从而抑制炎症反应,改善血管内皮舒缩功能,延缓病情进展,改善患者临床症状,体现中医药治疗优势,值得临床推广应用。Objective： To investigate the eftect on inflammatory factors and vascular endothelial growth factor by Yiqi Yangyin for patients with diabetic nephropathy. Methods： 60 patients with early diabetic nephropathy Qi in our hospital as research objects, and they were randomizedly divided into an observation group with 30 pa- tients and a the control group with 30 patients. Then both of the groups were given comprehensive treatment, and the observation group was with Yiqi Yangyin medicine, and the control group was treated with irbesartan and placebo, 3 months as a course of treatment. They were observed for six months before and after treatment according to tumor necrosis factor （ TNF - α）, interleukin - 6 （ IL - 6）, C - reactive protein （ CRP）, plasma endothelin （ET）and nitric oxide （NO）. Then we conducted a comprehensive evaluation. Results ：In the treat- ment groups TNF - α, IL - 6 and CRP were compared with those before treatment, the difference was statisti-cally significant （P 〈 0.05 ）. It was statistically significant as compared with the differences between two groups （P 〈 0. 05 ）. After two treatments ET and NO were compared with before treatment, the difference was statistically significant （ P 〈 0.05 ）. It was statistically significant as compared with the differences between two groups（P 〈0.05）. Conclusion：Yiqi Yangyin for diabetic nephropathy can reduce the body＇s level of inflam- matory factors, thereby it can inhibit inflammation, improve vascular function and improve clinical symptoms, which is worthy of clinical application.

关 键 词：益气养阴 糖尿病肾病早期 炎症因子 血管内皮因子 

分 类 号：R259[医药卫生—中西医结合]