血清分泌型卷曲相关蛋白5与早期糖尿病肾病的相关性研究  

Association analysis of serum SFRP5 level with early diabetic nephropathy

作　　者：刘云涛[1] 简磊[1] 潘敬芳[1] 

机构地区：[1]三峡大学仁和医院内分泌科,宜昌443000

出　　处：《中国糖尿病杂志》2016年第2期131-134,共4页Chinese Journal of Diabetes

摘　　要：目的探讨糖尿病慢性肾脏疾病(CKD)患者血清分泌型卷曲相关蛋白5(SFRP5)与早期糖尿病肾病(EDN)的相关性。方法选择新诊断单纯T2DM患者43例、EDN患者42例,另选择健康体检者(NC)42名。ELISA测定空腹血清SFRP5水平。结果 3组血清SFRP5水平依次为:NC组(5.02±0.69)μg/L,T2DM组(4.37±0.53)μg/L和EDN组(3.76±0.49)μg/L(P<0.05或P<0.01)。血清SFRP5水平与胰岛素抵抗指数(HOMA-IR)、FIns、FPG、HbA1c、BMI、IL-6、TG、TNF-α、UAER、尿白蛋白/肌酐(UAlb/Cr)、病程呈负相关(r=-0.573、-0.522、-0.589、-0.601、-0.467、-0.515、-0.542、-0.647、-0.592、-0.638、-0.553,P<0.05或P<0.01),与SOD呈正相关(r=0.603,P<0.01)。多元逐步回归分析显示,HOMA-IR、TNF-α、UAlb/Cr是SFRP5的独立影响因素。结论EDN患者血清SFRP5水平降低,血清SFRP5与EDN的严重程度相关。Objective To explore the association between serum secreted frizzled-related protein 5（SFRP5）and early diabetic nephropathy（EDN）. Methods A total of 127 subjects were enrolled in this study and divided into three groups：patients with newly diagnosed type 2diabetes（T2DM group,n=43）,patients with early diabetic nephropathy（EDN group,n=42）,and healthy subjects with normal glucose tolerance（NC group,n=42）.Serum SFRP5 was measured by ELISA. Results The serum SFRP5were（5.02±0.69）μg/L,（4.37±0.53）μg/L,and（3.76±0.49）μg/L in NC,T2 DM and EDN group respectively（P〈0.05 or P〈0.01）.（2）SFRP5were negatively correlated with HOMA-IR,FIns,FPG,HbA1 c,BMI,IL-6,TG,TNF-α,UAER,UAlb/Cr,and duration of diabetes（r=-0.573,-0.522,-0.589,-0.601,-0.467,-0.515,-0.542,-0.647,-0.592,-0.638,-0.553,P〈0.05 or P〈0.01）,and positively correlated with SOD（r=0.603,P 0.01）.Multiple linear regression analysis showed that HOMA-IR,TNF-α and UAlb/Cr were independent influencing factors for SFRP5.Conclusion Serum SFRP5 is decreased in patients with EDN.Serum SFRP5 is associated with severity of DN.

关 键 词：分泌型卷曲相关蛋白5 糖尿病 2型 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]