建立海水浸泡状态下猪腹部枪弹伤模型及致伤特点的研究  

Study of Establishing of Pig Abdomen Bullet Wound Model in Seawater Immersion Condition and Its Injury Characteristics

作　　者：林立英[1] 黄国良[1] 张再重[1] 姜一帆[1] 林孝文[1] 王烈[1] 

机构地区：[1]南京军区福州总医院普通外科,福建福州350025

出　　处：《中国普外基础与临床杂志》2016年第2期182-185,共4页Chinese Journal of Bases and Clinics In General Surgery

基　　金：南京军区医学科技创新项目(编号:13ZX29);南京军区医学科技创新项目(编号:14ZX25)~~

摘　　要：目的建立海水浸泡状态下猪腹部枪弹伤动物模型并分析其致伤特点。方法将20只西双版纳猪采用随机数字表法随机分成海水浸泡组和对照组,每组10只。海水浸泡组使用国产81-1式突击步枪距离10 m实弹射击固定于自制支架并半漂浮于海水中的猪左下腹反麦氏点致伤,致伤后浸泡60 min打捞出水;对照组在陆地上以同样方式致伤并等待60 min,不进行海水浸泡。致伤后1、4、8 h监测2组猪的平均动脉压(MAP)、肛温(RT)、心率(HR)、呼吸频率(R)、白细胞计数(WBC)、C反应蛋白(CRP)及死亡率指标。结果 1成功建立海水浸泡状态下猪腹部枪弹伤模型后,海水浸泡组伤后各时间点MAP、RT均明显低于对照组相应时相(P<0.05),伤后4 h和8 h时HR明显低于对照组相应时相(P<0.05),伤后8 h时R明显低于对照组相应时相(P<0.05)。2海水浸泡组与对照组的WBC在伤后4 h和8 h时较正常值明显升高、CRP在伤后1 h、4 h及8 h时较正常值明显升高,海水浸泡组在4 h和8 h时WBC明显高于对照组相应时相(P<0.05)、1 h、4 h及8 h时CRP均明显高于对照组相应时相(P<0.05)。3对照组在伤后8 h时死亡2只(20%),海水浸泡组在伤后8 h时死亡5只(50%),海水浸泡组伤后8 h时的死亡率明显高于对照组(P<0.05)。结论海水浸泡状态下的猪腹部枪弹伤模型的伤情更严重、感染时间提前且程度加重、死亡率高。Objective To establish pig abdomen bullet wound model in seawater immersion condition and to analyze injury characteristics. Methods Twenty Xishuangbanna pigs were randomly divided into seawater immersion group and control group, with 10 in each group. The left lower quadrant anti Mc Burney point of the pig semi-floating in the seawater was shot by using domestic 81-1 assault rifle at the distance of 10 meters, which were salvaged out of seawater at 60 minutes after injury in the seawater immersion group. The pigs in the control group were treated same as the seawater immersion group except seawater immersion. The mean arterial pressure（MAP）, rectal temperature（RT）, heart rate（HR）, respiratory（R）, white blood cell count（WBC）, and C-reactive protein（CRP） were tested at 1 h, 4 h, 8 h after injury. The death of pig was observed. Results The pig abdomen bullet wound models in the seawater immersion condition were successfully established. 1 Compared with the control group, the MAP and RT were significantly decreased at 1 h, 4 h,8 h after injury, the HR or the R was significantly decreased at 4 h or 8 h after injury respectively in the seawater immersion group. 2 Compared with the normal value, the WBC obviously rose at 4 h and 8 h after injury, the CRP obviously rose at 1 h, 4 h, and 8 h after injury in both two groups. Compared with the control group, the WBCs were significantly increased at 4 h and 8 h after injury（P〈0.05）, the CRPs were significantly increased at 1 h, 4 h, and 8 h after injury（P〈0.05） in the seawater immersion group. 3 The mortality in the seawater immersion group（50%） was significantly higher than that in the control group（20%, P〈0.05）. Conclusion The injury is more serious, the infection time is earlier, and the infection degree is aggravated, the mortality rate is higher for pig abdomen bullet wound model in seawater immersion condition.

关 键 词：海水浸泡 腹部枪弹伤 动物模型 

分 类 号：R82[医药卫生—临床医学] R-332