NOS3参与心血管疾病调控机制研究进展  

Research Progress of NOS3 Participation in Regulatory Mechanisms of Cardiovascular Diseases

作　　者：孙婷[1] 池晴佳(综述) 王贵学(审校)[1] 

机构地区：[1]重庆大学生物工程学院,生物流变科学与技术教育部重点实验室,重庆市血管植入物工程实验室,重庆400044

出　　处：《生物医学工程学杂志》2016年第1期188-192,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(11332003,81400329);重庆市博士后研究基金(Xm2014027)

摘　　要：在心血管疾病的发生过程中,常出现内皮功能紊乱等初期症状,而此过程与一氧化氮(NO)介导的血管舒张密切相关,NO的释放是由内皮一氧化氮合酶NOS3所调控。近期研究表明,心血管疾病常常伴随着NOS3基因多态性变化及表观遗传学修饰,而现有研究对于NOS3表观遗传学及基因多态性对于心血管疾病调控机制及靶向治疗研究关注较少。本文综述了近年来关于NOS3在心血管系统相关疾病中的研究现状,总结了其在各类疾病发病过程中的分子机制,重点阐述了NOS3蛋白解离、NOS3表观遗传修饰及多态性在心血管疾病发生发展中的作用,并为相关疾病药物开发的治疗靶点设计提供参考。Cardiovascular disease has been a major threat to human＇s health and lives for many years.It is of great importance to explore the mechanisms and develop strategies to prevent the pathogenesis.Generally,cardiovascular disease is associated with endothelial dysfunction,which is closely related to the nitric oxide（NO）-mediated vasodilatation.The release of NO is regulated by NOS3 gene in mammals＇ vascular system.A great deal of evidences have shown that the polymorphism and epigenetic of NOS3 gene play vital roles in the pathological process of cardiovascular disease.To gain insights into the role of NOS3 in the cardiovascular diseases,we reviewed the molecular mechanisms underlying the development of cardiovascular diseases in this paper,including the uncoupling of NOS3 protein,epigenetic and polymorphism of NOS3 gene.The review can also offer possible strategies to prevent and treat cardiovascular diseases.

关 键 词：NOS3 心血管系统 蛋白解离 表观遗传 多态性 

分 类 号：R54[医药卫生—心血管疾病] R34[医药卫生—内科学]