磷脂囊泡在胺端基和羧端基修饰金表面的沉积  

Deposition of lipid vesicles on amine/carboxyl-end-modified gold substrates

作　　者：张国梁[1] 尼亚孜别克[1] 杨方源[2] 盛洁[1] 

机构地区：[1]伊犁师范学院电子与信息工程学院,伊宁835000 [2]新疆大学物理学院,乌鲁木齐210093

出　　处：《原子与分子物理学报》2016年第1期121-127,共7页Journal of Atomic and Molecular Physics

基　　金：国家自然科学基金(21264016;21364016);伊犁师范学院青年科研基金(2013YSYB19)

摘　　要：磷脂囊泡与阴,阳离子性表面作用的深入理解对磷脂的生物纳米科技应用具有重要意义.通过石英电子微天平及耗散系数测量仪,研究了不同离子性磷脂囊泡在胺端基和羧端基修饰Au衬底的沉积行为.实验观察到四条囊泡沉积路径:(ⅰ)吸附至临界值后破裂成膜;(ⅱ)吸附即破裂成膜;(ⅲ)吸附不破裂;(ⅳ)不吸附.沉积路径由囊泡与衬底的双电层相互作用决定,离子可发挥调节作用.Understanding the interaction mechanism between cal to the application of lipids in bionanotechnology. The lipid vesicles and cationic/anionic surfaces is criti- adsorption behavior of lipid vesicles with diverse ionic properties on amine-end-modified and carboxyl-end-modified gold substrates was studied by quartz crystal mi- crobalance with dissipation monitoring. Four different vesicle deposition pathways have been observed including： （ i ） adsorption till the critical value then rupture to form supported membranes; （ ii ） adsorption and rupture simultaneously; （iii ） adsorption without rupture ; and （ iv ） no adsorption. The deposition pathway is deter- mined by the double layer force between vesicles and substrate. Ion may regulate the deposition process.

关 键 词：磷脂 胺 羧 沉积 支撑膜 

分 类 号：O552.6[理学—热学与物质分子运动论]