瘦素受体基因Gln223Arg多态性与代谢综合征的相关性及其对心脏结构功能的影响  

Relationship Between Leptin Receptor Gene Gln223Arg Polymorphism and Metabolism Syndrome With its Impact on Left Ventricular Hypertrophy

作　　者：陈海翎[1] 王倩[1] 李菊芬[1] 邓丽丽[1] 

机构地区：[1]北京积水潭医院内分泌科,北京市100035

出　　处：《中国循环杂志》2016年第2期127-131,共5页Chinese Circulation Journal

基　　金：北京市保健专项资金资助项目(项目编号:京06-09号)

摘　　要：目的：探究瘦素受体基因Gln223Arg多态性与代谢综合征的相关性及其对心脏结构功能的影响。方法：研究对象为2005—10至2008—06我院门诊初诊未治疗的167例代谢综合征患者f代谢综合征组）和216例健康体检者（对照组）。测量血压、生化指标、胰岛素及超声心动图等，限制性片段长度多态性聚合酶链（PCR—RFLP）法分析Gln223Arg基因多态性和测序验证基因型。结果：代谢综合征组携带A等位基因频率明显高于对照组，携带A等位基因者发生代谢综合征的几率是携带G等位基因的3．302倍畔=O．000；95％可信区间（CI）：2．432～4．483]。初诊而未治疗的代谢综合征患者已出现左心室肥厚重构和舒张功能减低。代谢综合征组携带A等位基因的患者较携带G等位基因者有更高的体重指数、血压、血糖和空腹胰岛素水平，更大的腰围，更严重的血脂紊乱、胰岛素抵抗、左心室肥厚及舒张功能减低。结论：瘦素受体基因G1n223Arg多态性A等位基因携带者发生代谢综合征的风险较大，更倾向于发生左心室肥厚。Objective： To explore the relationship between leptin receptor gene Gln223Arg polymorphism and metabolism syndrome （MS） with its impact on cardiac structure and function. Methods： Our research included 2 groups： MS group, n=167 patients with first diagnosed MS without treatment in our hospital from 2005-10 to 2008-6 and Control group, n=216 healthy subjects from regular physical examination. Blood pressure, biochemical features, insulin levels and echocardiography were detected; leptin receptor Gln223Arg genotypes were measured by PCR-RFLP; the above indexes were compared between 2 groups. Results： The patients in MS group had the higher frequency of A allele than Control group. The MS occurrence rate in allele A cartier was 3.302 times higher than allele G cartier （P=0.000; 95% CI 2.432-4.483）. The patients in MS group already had left ventricular hypertrophy and impaired diastolic function. Compared with MS G allele carriers, the A allele carriers had the higher BMI, blood pressure, glucose, fasting glucose and insulin levels, longer waist circumference, more serious dyslipidemia and insulin resistance, left ventricular hypertrophy and impaired diastolic function. Conclusion： Leptin receptor gene Gln223Arg polymorphism is associated with the increased risk of MS occurrence and left ventricular hypertrophy.

关 键 词：受体 瘦素 多态性 单核苷酸 肥大 左心室 代谢综合征 

分 类 号：R541.6[医药卫生—心血管疾病]