中老年人群心血管健康指标变化与动脉僵硬度的关系  

Relationship Between the Changes of Cardiovascular Health Indicator and Arteriosclerosis in Middle and Elder Population

作　　者：杜鑫[1] 刘妍[1] 张莹 施继红[1] 黄喆[1] 朱辰蕊[1] 李慧英[1] 魏晓明[1] 林黎明[1] 熊海亮[1] 季春鹏[1] 吴寿岭[1] 

机构地区：[1]开滦总医院心内二科,河北省唐山市063000 [2]华北理工大学附属医院超声科

出　　处：《中国循环杂志》2016年第2期137-141,共5页Chinese Circulation Journal

摘　　要：目的：探讨中老年人群心血管健康指标变化与动脉僵硬度的关系。方法：从2006年～2011年3次开滦集团职工体检者中，随机分层抽取增加了臂踝动脉脉搏波传导速度（baPWV）测定的体检者4190例，基线时平均年龄（49．78±9．74）岁。按照美国心脏协会（AHA）提出的7项心血管健康指标标准（不吸烟、正常体重指数、积极体育锻炼、健康饮食、正常胆固醇水平、正常血压水平、正常空腹血糖水平），每项指标分理想、一般、差3级，分别为2、1、0分。根据第1次、第3次体检的心血管健康评分变化（△CHS），将研究人群分为8组（依次为△CHS≤-4、-3、-2、-1、0、1、2、≥3分组，分别为241、368、611、855、911、647、354、203例）。采用线性回归、Logistic回归分析不同△CHS对baPWV的影响。结果：随着△CHS由低向高转变（依次为aCHS≤-4、-3、-2、-1、0、1、2、≥3分组），baPWV值逐渐降低分别为（1590．78±17．93、1566．4±14．5、1552．83±11．25、1536．59±9．51、1508．85±9．21、1499．81±10．93、1485．92±14．82、1475．85±19．57）cm／s。多元线性回归分析显示：在校正多种混杂因素之后，△CHS每增加1分，baPWV减少15．58cm／s（B=-15．58，P〈0．001）。Logistic回归分析显示：在校正多种混杂因素之后，△CHS每增加1分，罹患动脉僵硬的风险降低14％（比值比=0．86，95％可信区间：0．83～0．90）。结论：aCHS与baPWV呈负相关。改善心血管健康指标可以降低中老年人群患动脉僵硬的风险。Objective： To investigate the changes of cardiovascular health indicator and arteriosclerosis in middle and elder population. Methods： A total of 4190 subjects with the average age of （49.78 ± 9.74） years by 3 physical examinations in Kailuan group from 2006 to 2011 were randomly stratified for arm ankle arterial pulse wave velocity （baPWV） examination. According to 7 AHA cardiovascular health indicators of non-smoking, normal BMI, active excise, healthy diet, normal cholesterol, blood pressure and fasting blood glucose, each indicator had 3 conditions as ideal, general and poor by scores of 2, 1 and 0 respectively. Based on the 1^st and 3^rd physical examinations, the changes of cardiovascular health scores （△CHS）, the subjects were divided into 8 groups as A CHS 〈 -4, -3, -2, -1, 0, 1, 2 and △ CHS〉 3, n=241,368, 611,855, 911,647, 354 and 203 respectively. The impacts of△CHS on baPWV values were studied by liner and Logistic regression analyses. Results： As △CHS increased by △CHS 〈 -4, -3,-2,-1,0,1, 2 and A CHS 〉 3, the baPWV values were decreased accordingly by cm/s as （1590.78 ± 17.93）, （1566.4 ± 14.5）, （1552.83 ± 11.25）, （1536.59 ± 9.51）, （1508.85 ± 9.21）, （1499.81 ± 10.93）, （1485.92 ± 14.82） and （1475.85 ± 19.57） respectively. Multiple linear regression analysis showed that with adjusted confounding factors, as △CHS increasing 1 score, baPWV increasing 15.58 cm/s （B=15.58, P〈0.001）. Logistic regression analysis indicated that with adjusted confounding factors, as △CHS increasing I score, the risk for arteriosclerosis occurrence was decreased by 14% （OR=0.86, 95% CI 0.83-0.90）. Conclusion： △CHS was negatively related to baPWV in middle and elder subjects, improving cardiovascular health indicator may decrease arteriosclerosis occurrence.

关 键 词：心血管系统 健康状况 动脉僵硬度 

分 类 号：R54[医药卫生—心血管疾病]