Cu(Ⅰ)催化下2,3-二氢-1,4-苯并二噁烷类化合物的合成  

Cu( Ⅰ)-Catalyzed Synthesis of2,3-Dihydro-1,4-Benzodioxins

作　　者：史兰香[1] 张宝华[1] 

机构地区：[1]石家庄学院化工学院,石家庄050035

出　　处：《应用化学》2016年第2期144-148,共5页Chinese Journal of Applied Chemistry

基　　金：河北省科技支撑项目(15226601D);石家庄学院平台基金项目(XJPT007)~~

摘　　要：以Cu Br为催化剂,1,4,7-三氮杂环壬烷衍生物为配体,K2CO3为碱,110℃下通过取代的邻碘代酚和取代的环氧化物的串联反应制备了2,3-二氢-1,4-苯并二噁烷类化合物。各种芳香取代的环氧化物和脂肪取代的环氧化物均能顺利的与邻碘代酚反应,产物收率64%-83%。讨论了底物取代基与产物收率的关系,推测了反应机理。并用NMR和元素分析确定了产物结构。2,3-Dihydro-1,4-benzodioxins were prepared through a tandem reaction of epoxides and o-iodophenols catalyzed by Cu Br /1,4,7-trisubstituted-1,4,7-triazonane with K2CO3 as the base at 110 ℃. All aryl and aliphatic epoxides reacted with o-iodophenols smoothly with yields of 64% - 83%. The relationship between yields and substituent groups was described and the possible mechanism was discussed. The compounds were confirmed by NMR and element analysis.

关 键 词：二氢-苯并二噁烷 邻碘代酚 环氧化物 三氮杂环壬烷衍生物 

分 类 号：O621.2[理学—有机化学]