2,6-二溴甲基吡啶的合成研究  

STUDY ON SYNTHESIS OF 2,6-DIBROMOMETHYLPYRIDINE

作　　者：张精安[1] 邹训重[2] 刘亚杰[2] 张莉杰[2] 程燕芳[1] 高银谊 黄秋容[1] 戈杰[1] 

机构地区：[1]广东药科大学药学院,广东广州510006 [2]广东药科大学中药学院,广东广州510006

出　　处：《精细石油化工》2016年第1期27-29,共3页Speciality Petrochemicals

基　　金：广东省建设科技思想库研究课题项目(2014GDSXK011);广东药科大学2015年国家级;省级;校级大学生创新创业训练计划项目(201510573012)

摘　　要：以2,6-二甲基吡啶为原料,经过氧化、酯化、还原、溴代等合成了2,6-二溴甲基吡啶,四步总收率43.8%。探讨了不同催化剂对反应收率的影响。采用对甲苯磺酸为酯化反应的催化剂,用硼氢化钠和无水路易斯酸为酯的还原剂代替昂贵的氢化铝锂,操作简便,使用安全。2,6-Dihydroxymethylpyridine was prepared by oxidation,esterification,reduction,bromination reactions through the raw material 2,6-dimethylpyridine.The effect of different catalysts on the reaction yield was investigated.The total yield is 43.8%,was higher than the literature value.Using p-toluene sulfonic acid as catalyst for the esterification reaction,sodium borohydride and Lewis acid as reductant of ester instead of expensive aluminium hydride lithium,the operating method of the synthesis of 2,6-dihydroxymethylpyridine was easy,safe and cheap for the operation and more in line with the requirements of modern synthetic methods.

关 键 词：2 6-二溴甲基吡啶 2 6-二羟甲基吡啶 2 6-吡啶二甲酸二乙酯 合成 

分 类 号：TQ253.21[化学工程—有机化工]