基于EQ-5D量表的中国疾病人群生命质量系统评价  

Health-Related Quality of Life for Disease Population in China based on EQ-5D:A Systematic Review

作　　者：周挺[1] 官海静[2] 刘国恩[2,3] 马爱霞[1] 

机构地区：[1]中国药科大学国际医药商学院,南京211198 [2]北京大学中国卫生经济研究中心,北京100080 [3]北京大学国家发展研究院,北京100871

出　　处：《中国循证医学杂志》2016年第2期135-142,共8页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金(编号:71273015)

摘　　要：目的基于EQ-5D量表,系统评价中国不同疾病人群的生命质量。方法计算机检索PubMed、The Cochrane Library（2015年第5期）、EMbase、CNKI、VIP和WanFang Data数据库,搜集国内外公开发表的中国疾病人群生命质量研究,检索时限均为建库至2015年8月。按病种梳理各种疾病患者健康效用值,分析5个维度出现问题的比例,并比较不同疾病人群的生命质量的差异。结果最终纳入26篇文献,包含15种疾病。同种疾病不同研究的健康效用值存在一定差异,糖尿病为0.79~0.94,乙肝病毒感染肝病为0~0.80,高血压为0.78~0.93,冠心病为0.75~0.90,慢性阻塞性肺炎为0.64~0.73。对15种疾病的健康效用均值排序后发现儿童脑瘫最低,为0.44,其次是大骨节病和类风湿性关节炎,分别为0.45和0.56。对于多数疾病患者,＂疼痛或不舒服＂维度出现问题比例最高,但房颤患者和儿童脑瘫患儿在＂自我照顾＂或＂日常活动＂两个维度存在问题的比例最高。结论 EQ-5D量表在中国疾病人群的生命质量研究中应用广泛,包括样本来源、疾病严重程度、合并症情况、积分体系等诸多因素对健康效用值的测量结果有影响。Objective To systematically review the health-related quality of life（QOL） based on EQ-5D instrument for disease population in China.Methods We searched databases including PubMed,The Cochrane Library（Issue5,2015）,EMbase,CNKI,VIP and WanFang Data from inception to August 2015,to identify studies involving healthrelated QOL about different diseases in China.A descriptive analysis was used to analyze health utility by disease and the proportion of patients who having problem in five dimensions,as well as comparing health-related QOL in different diseases.Results A total of 26 studies were included,involving 15 kinds of diseases.The health utility in different studies about the same disease was different.Diabetes ranged from 0.79 to 0.94,liver disease infected by HBV was from 0 to 0.80,hypertension was from 0.78 to 0.93,coronary heart disease was from 0.75 to 0.90,and chronic obstructive pulmonary disease was from 0.64 to 0.73.After ranking the health utility of fifteen kinds of diseases,the utility of kashin-beck disease and rheumatoid arthritis were 0.45 and 0.56,respectively,and the utility of children cerebral palsy was 0.44,which was the lowest. ＂Pain/discomfort＂ was the dimension with highest proportion of patients who having problem for most diseases while atrial fibrillation and children cerebral palsy were the ＂Self-care＂ and ＂Usual Activities＂.Conclusion EQ-5D is widely used in health-related QOL studies among different diseases in China.Many factors including sample source,severity of disease,complication and value set have influence on the measurement results of health utility.

关 键 词：EQ-5D 中国疾病人群 生命质量 系统评价 

分 类 号：R195.4[医药卫生—卫生统计学]