肝病生存质量量表在慢性病毒性肝炎患者中的性能评估  

Reliability, validity and responsiveness of the Chinese version of Liver Disease Quality of Life Questionnaire in viral hepatitis patients

作　　者：齐明华[1] 彭雁忠[1] 李佳玲 郝元涛[2] 周元平[3] 

机构地区：[1]北京大学深圳医院感染疾病科,广东省深圳市518036 [2]中山医科大学统计教研室,广东省广州市510080 [3]南方医科大学南方医院感染内科,广东省广州市510515

出　　处：《世界华人消化杂志》2016年第2期272-278,共7页World Chinese Journal of Digestology

基　　金：深圳市科技研发基金资助项目;No.JCYJ20120831144704365~~

摘　　要：目的:探讨肝病生存质量量表(Liver Disease Quality of Life Questionnaire,LDQOL1.0)中文版在慢性病毒性肝炎患者生存质量测试中的信度和效度.方法:使用LDQOL1.0中文版对100例慢性病毒性肝炎患者进行进行生存质量测试,回收有效问卷91例,使用克朗巴赫系数(Cronbachα)、天花板效应和地板效应来检测量表的信度;通过计算各个肝病特异性维度与S F-36的8个维度之间的相关系数来评估量表的标准效度;通过探索性因子分析来评估量表的结构效度;通过比较不同Child Pugh评分的患者的得分,评估量表的区分度.相关性检测使用Pearson相关系数,区分度检测使用方差分析进行多重比较.结果:Cronbach α在各领域中的分值为0.33(95%C I:0.08-0.52)-0.9(95%C I:0.90-0.99),80%领域分值>0.7;天花板效应在0%-39.6%,地板效应在0%-34.1%,80%领域<20%.标准效度提示12个肝病特异性领域里,有6个领域与SF-36的相近领域相关度较好(Pearson系数>0.5,P<0.05);因子分析提示肝病特异性12个领域里7个领域因子分析结果与原量表构想相似.区分度检测提示肝病特异性12个领域里7个的区分度较好(F:0.353-21.29,P<0.05).结论:LDQOL1.0在中国慢性病毒性肝炎患者中测试生存质量,大部分领域信度、效度和区分度较好,可以用于临床工作.AIM To determine the reliability, validity and responsiveness of the Chinese version of Liver Disease Quality of Life Questionnaire （LDQOL1.0） in viral hepatitis patients. METHODS： The questionnaire was administered to 100 patients with viral hepatitis and 91 returned the questionnaire. Cronbach , ceiling effect and flooring effect were calculated to test the reliability of this questionnaire. Relationship coefficients between liver disease specific dimensions and SF-36 were calculated to test the standard validity of the questionnaire. Exploring factor analysis was used to test the questionnaire＇s construct validity. Responsiveness was tested by comparing scores of patients with different Child Pugh scores. Pearson coefficient was used to show the relationship and ANOVA analysis was used to test responsiveness.RESULTS： Cronbach ~ ranged from 0.33 （95%CI： 0.08-0.52） to 0.9 （95%CI： 0.90-0.99）, and 80% of domains had a Cronbach c~ valuehigher than 0.7. Ceiling effects ranged from 0% to 39.6%, and flooring effects ranged from 0% to 34.1%, with most domains having the values less than 20%. Six of twelve domains were related closely with SF-36 （Pearson coefficient 〉 0.5, P 〈 0.05）. Exploring factor analysis showed that 7 of 12 domains concurred with original imagination. Responsiveness showed that 6 of 12 domains were good （F： 0.353-21.29, P 〈 0.05）. CONCLUSION： Most domains of LDQOL1.0 had good reliability, validity and responsiveness when it was used to test quality of life in Chinese patients with viral hepatitis.

关 键 词：肝病生存质量量表 慢性病毒性肝炎 信度 效度 

分 类 号：R512.6[医药卫生—内科学]