微RNA在银屑病中差异表达的研究进展  

Research Advances of miRNA Differential Expression in Psoriasis

作　　者：陈春丽[1,2] 刘新梅[1] 普雄明[1] 吴卫东[3] 

机构地区：[1]新疆维吾尔自治区人民医院皮肤性病科,乌鲁木齐830001 [2]石河子大学医学院,新疆石河子832000 [3]新疆维吾尔自治区人民医院临床医学研究中心,乌鲁木齐830001

出　　处：《医学综述》2016年第3期443-446,共4页Medical Recapitulate

基　　金：新疆维吾尔自治区自然科学基金(2015211C201)

摘　　要：若干微RNA(miRNA)的异常表达可通过作用于一个或多个靶基因在银屑病的发病中发挥重要作用,如miR-99a、miR-486-3p、miR-210可分别作用于胰岛素样生长因子1受体、叉头状转录因子3及人相关转录因子3等靶点。miRNA可调节角质形成细胞的异常增殖、分化及增加炎性介质的表达水平,通过研究miRNA在银屑病中的差异表达可找到更为有效的治疗方法。希望通过对miRNA生物合成、作用机制及与银屑病相关性的研究,为银屑病的病理生理机制及治疗提供一些新的思路。Several miRNA abnormal expression plays an important role in psoriasis by acting on one or more target genes,for example,miR-99a,miR-486-3p,miR-210 act respectively on target genes IGF-1R, FOXP3 and RUNX3 and so on. Specifically, themiRNAs can adjust abnormal proliferation and differentiation of keratinocytes and increase expression levels of inflammatory mediators. By researching it in psoriasis can find an effective therapeutic modality. Here we hope that the research on biosynthesis and mechanism of miRNA, and the relationship between psoriasis and miRNA can provide new insights for the pathophysiology and therapy of psoriasis.

关 键 词：银屑病 微RNA 差异表达 靶基因 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]