生长抑素对开腹手术肠梗阻患者的治疗效果  

The Therapeutic Effect of Somatostatin on Intestinal Obstruction after Laparotomy

作　　者：郭峰[1] 艾旭[2] 龙舟[1] 马旭[1] 梅丹丹[1] 

机构地区：[1]荆门市第一人民医院普外科,湖北荆门448000 [2]荆门市第一人民医院南院肛肠科,湖北荆门448000

出　　处：《医学综述》2016年第3期575-577,共3页Medical Recapitulate

摘　　要：目的探讨生长抑素对开腹手术肠梗阻患者的治疗效果。方法选择2013年2月至2015年2月荆门市第一人民医院接诊的开腹肠梗阻手术患者80例按随机数字表法分成对照组和观察组,各40例。对照组患者给予补液纠正其酸碱与水电解质失衡,患者常规进行补充营养,实施胃肠道的减压,对患者抗感染、全肠外营养,观察组在此基础给予生长抑素静脉滴注3 mg,溶于0.9%Na Cl注射液,对比分析两组患者的疗效情况。结果观察组总有效率显著高于对照组[100.0%(40/40)比50.0%(20/40)],差异有统计学意义(P<0.01);治疗后观察组排便、排气、腹痛缓解、腹胀缓解的改善率显著高于对照组[97.5%(39/40)比47.5%(19/40);87.5%(35/40)比42.5%(17/40);100.0%(40/40)比50.0%(20/40);90.0%(36/40)比40.0%(16/40)],差异有统计学意义(P<0.01)。治疗后观察组肠减压量显著少于对照组[(262±56)m L比(402±114)m L],差异有统计学意义(P<0.01)。治疗后观察组KPS评分显著高于对照组[(85±10)分比(71±9)分],差异有统计学意义(P<0.01)。结论生长抑素防治开腹手术患者肠梗阻的效果良好,也能提高患者的生活质量,值得在临床中推广和应用。Objective To study the therapeutic effect of somatostatin on intestinal obstruction after laparotomy. Methods Total of 80 cases of intestinal obstruction after laparotomy in the First People＇s Hospital of Jingmen city from Feb. 2013 to Feb. 2015 were included in the study. They were divided into observation group and control group with 40 patients each, according to random number table method：the control group received conventional treatment approaches of fluid I plus nfusion to correct acid-base and water electrolyte imbalance plus nutrition supplement plus gastrointestinal decompression plus anti-infection and total paren- teral nutrition, and the observation group was given somatostatin （3 mg saluted in 0. 9% NaCl injection,iv. ） on the basis of control group＇s treatment. The therapeutic efficacy of the two groups were analyzed and com- pared. Results Total efficacy of the observation group was 100. 0%, significantly higher than the control group＇s 50. 0%, the difference was statistically significant （ P 〈 0. 05 ） ; after treatment, the defecation, gas exhaust,abdominal pain, bloating improvement/remission rate of the observation group were significantly higher than the control group [ 97.5 % （39/40） vs 47.5 % （19/40） ; 87.5 % （35/40） vs 42.5 % （ 17/40 ） ; 100. 0% （40/40） vs 50. 0% （20/40） ;90. 0% （36/40） vs 40. 0% （16/40） ] ,the differences were statisti- cally significant（P 〈 0. 01 ）. Intestinal decompression after treatment in the observation group was signifi- cantly lower than the control group[ （262 ±56） mL vs （402 ± 114） mL] ,the difference was statistically significant （P 〈 0. 05 ）, KPS score after treatment in the observation group was significantly higher than the control group[ （85 ± 10 ） scores vs （71 ± 9 ） scores ], the difference was statistically significant （P 〈 0.01 ）. Conclusion Somatostatin has good therapeutic effect on intestinal obstruction in patients with laparotomy and improve the quality of life of

关 键 词：肠梗阻 生长抑素 开腹手术 

分 类 号：R656[医药卫生—外科学]