无溶剂研磨法快速合成3-芳乙烯基-1,5-二酮类化合物的反应研究  

Study on the Grinding-Induced Solvent-Free Preparation of 3-Styryl-1,5-diketones

作　　者：王克虎[1] 殷雪娇[1] 陶瑞[1] 黄丹凤[1] 苏瀛鹏[1] 胡雨来[1] 傅颖[1] 杜正银[1] 王进贤[1] 

机构地区：[1]西北师范大学化学化工学院,兰州730070

出　　处：《有机化学》2016年第1期113-120,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21262031)资助项目~~

摘　　要：在无溶剂条件下,α,β-不饱和醛与芳香酮在室温下研磨得到2,4-共轭二烯酮,随后,2,4-共轭二烯酮与过量芳香酮在Na OH存在下进一步发生Michael加成反应,快速而高效地合成了3-芳乙烯基-1,5-二酮类化合物.该法与传统的溶液法相比具有不使用溶剂和催化剂,反应条件温和,反应时间短,操作简便等优点.A convenient procedure for the synthesis of 3-styryl-1,5-dicarbonyl compounds has been developed under solvent-free grinding conditions. α,β-Unsaturated aldehydes react with aromatic ketones to give the corresponding dienone products, then followed by a Michael addition producing 3-styryl-1,5-dicarbonyl compounds in the presence of Na OH at room temperature. The advantages of this procedure are solvent-free, catalyst-free, mild reaction conditions, simple procedure, and short reaction time.

关 键 词：无溶剂 研磨 Aldol-Michael加成 1 5-二酮 

分 类 号：O621.3[理学—有机化学]