腹腔镜下行保留肾单位的肾肿瘤切除术对患者氧化应激反应以及红细胞糖代谢的影响  

Influence of laparoscopickindey tumorresectionon patients＆#39;oxidative stress and erythrocyte glucose metabolism

作　　者：杨渝[1] 邵志强[1] 郭嘉祥 

机构地区：[1]解放军总医院第一附属医院泌尿外科,北京100048

出　　处：《国际泌尿系统杂志》2016年第1期52-54,共3页International Journal of Urology and Nephrology

摘　　要：目的 分析腹腔镜下行保留肾单位肾肿瘤切除术对患者氧化应激反应以及红细胞糖代谢的影响.方法 选择接受手术治疗的肾肿瘤患者作为研究对象,按照手术方式不同分为观察组（腹腔镜手术）及对照组（开放性手术）.检测分析两组患者的围术期氧化应激反应、红细胞糖代谢水平、微炎症水平等差异.结果 观察组患者接受腹腔镜手术治疗后的丙二醛（MDA）、皮质醇（Cor）水平低于对照组,谷胱甘太（GSH）、超氧化物歧化酶（SOD）水平高于对照组患者（P＜0.05）;观察组患者的术后磷酸果糖激酶（PEK）水平高于对照组,红细胞6-磷酸葡萄糖胱氢酶（G-6PD）及醛糖还原酶（AR）水平低于对照组患者（P＜0.05）;观察组患者的术后C反应蛋白（CRP）、IL-6、TNF-α水平低于对照组患者（P＜0.05）.结论 腹腔镜下手术可以有效减少手术过程中的氧化应激反应,优化红细胞糖代谢,降低全身炎症反应,相较于开放性手术具有更多优势.Objectives Analyzedthe influence of laparoscopic kindey tumorresectionon patients＆#39; oxidative stress and erythrocyte glucose metabolism.Methods Kindey tumorpatients were choosedas research subjects and divided into observation group （laparoscopic surgery） and control group （open surgery）according to Surgical approach.Detected two group patients＆#39;perioperative oxidative stress and erythrocyte glucose metabolismlevels.Results The observation group patients MDA, Cor levels were lower than control after laparoscopic surgery, GSH, SOD levelswere higher than control group patients （P 〈0.05）;observation group patientsPFK level was higher than thatofcontrol group patients, G-6PD and AR levels were lower than control group patients（P 〈0.05）;observation group patients CRP,IL-6,TNF-α levels were lower than control group patients （P 〈 0.05）.Conclusions Laparoscopickindey tumorresection can reduce patients oxidative stress after surgery, optimizepatientserythrocyte glucose metabolism and systemic inflammationlevels, has many advantages over traditional open surgery.

关 键 词：腹腔镜检查 肾肿瘤/外科学 肾单位/外科学 氧化性应激 红细胞/代谢 葡萄糖/代谢 

分 类 号：R655[医药卫生—外科学]