槐杞黄颗粒对儿童孤立性血尿的疗效观察  

The observation of yellow huaiqi particles＆#39; efficacy on the children＆#39;s Isolated hematuria

作　　者：朱晟[1,2] 李志辉[2] 康志娟[2] 银燕[2] 王成[1] 

机构地区：[1]中南大学湘雅二医院儿科,湖南长沙410000 [2]湖南省儿童医院肾病研究室,湖南长沙410007

出　　处：《国际泌尿系统杂志》2016年第1期91-95,共5页International Journal of Urology and Nephrology

摘　　要：目的 通过观察槐杞黄颗粒对孤立性血尿患儿的治疗效果,为临床治疗儿童孤立性血尿可能提供新的方法及思路.方法 将2007年至2014年收治入院的326例儿童孤立性血尿患者根据口服的药物不同随机分为槐杞黄治疗组、VitE治疗组及空白组,观察其血尿阴转时间及阴转率,分析槐杞黄颗粒治疗孤立性血尿阴转的肾脏病理.结果 随访6个月,空白组有10/104例患儿血尿转阴,槐杞黄治疗组有46/116例患儿血尿转阴,VitE治疗组有10/106例患儿血尿转阴.经槐杞黄治疗发生阴转的肾脏病理改变类型及病例数分别为MsPGN.28例,IgM肾病12例,IgA肾病4例,C3肾病2例.6例IgG肾病的孤立性血尿患儿口服槐杞黄未见血尿阴转病例,槐杞黄治疗组中28例阴转的MsPGN中表现为肾小球系膜IgG沉积10例中未见阴转病例.结论 槐杞黄颗粒对儿童孤立性血尿阴转有一定的疗效,可能对于免疫机制介导的血尿疗效更好.槐杞黄颗粒对于IgM肾病效果较好,对于IgA肾病可能有效.Objectives To provide new methods and ideas for the clinical treatment of children with isolated hematuria by observing the Yellow Huaiqi particles＆#39; curative effect.Methods Divide 326 children who received in the hospital from 2007 to 2014 into Yellow Huaiqi treatment group, VitE treatment group and blank group respectively according to different oral drugs they took, observe their hematuria negative conversion time and negative conversion rate, analyze the renal pathology of Yellow Huaiqi particles＆#39; treatment of isolated hematuria negative conversion.Results During six months＆#39; following up, 10 of the 104 patients＆#39; hematuria in the blank group turned negative, 46 of the 116 patients＆#39; hematuria in the Yellow Huaiqi treatment group became negative, and 10 of 106 patients＆#39; hematuria in the VitE treatment group turned negative.The types of the renal pathology changes and cases that received Yellow Huaiqi treatment are 28 patients with MsPGN, 12 patients with lgM pathology,4 patients with lgA pathology and 2 patients with C3 pathology.6 isolated hematuria patients with lgM renal pathology haven＆#39; t showed the hematuria negative conversion after they took the Yellow Huaiqi particles, 10 of the 28 MsPGN cases in the Yellow Huaiqi treatment group that witnessed negative conversion showed mesangial IgG deposition didn＆#39; t manifest negative conversion condition.Conclusions The Yellow Huaiqi particles have a certain effect on children＆#39; s isolated hematuria negative conversion and may have a better efficacy to the hematuria mediated by the immune mechanism.The Yellow Huaiqi particles work well on the lgM nephropathy and may be effective to the lgA nephropathy.

关 键 词：中成药 血尿/中药疗法 

分 类 号：R726.958[医药卫生—儿科]