The progress in optic nerve regeneration, where are we?  

作　　者：Jennifer Wei Huen Shum Kai Liu Kwok-fai So 

机构地区：[1]Department of Ophthalmology, The University of Hong Kong [2]Division of Life Science, State Key Laboratory of Molecular Neuroscience, and Center of Systems Biology and Human Health, School of Science and Institute for Advance Study, The Hong Kong University of Science and Technology [3]GHM Institute of CNS Regeneration, Jinan University

出　　处：《Neural Regeneration Research》2016年第1期32-36,共5页中国神经再生研究（英文版）

基　　金：supported by National Program on Key Basic Research Project of China(973 Program;2011CB707501);Funds of Leading Talents of Guangdong(2013);Program of Introducing Talents of Discipline to Universities(B14036)

摘　　要：Optic nerve regeneration is an important area of research. It can be used to treat patients suffering from optic neuropathy and provides insights into the treatment of numerous neurodegenerative diseases. There are many hurdles impeding optic regeneration in mammals. The mammalian central nervous system is non-permissive to regeneration and intrinsically lacks the capacity for axonal regrowth. Any axonal injury also triggers a vicious cycle of apoptosis. Understanding these hurdles provides us with a rough framework to appreciate the essential steps to bring about optic nerve regeneration： enhancing neuronal survival, axon regeneration, remyelination and establishing functional synapses to the original neuronal targets. In this review article, we will go through current potential treatments for optic nerve regeneration, which includes neurotrophic factor provision, inflammatory stimulation, growth inhibition suppression, intracellular signaling modification and modeling of bridging substrates.Optic nerve regeneration is an important area of research. It can be used to treat patients suffering from optic neuropathy and provides insights into the treatment of numerous neurodegenerative diseases. There are many hurdles impeding optic regeneration in mammals. The mammalian central nervous system is non-permissive to regeneration and intrinsically lacks the capacity for axonal regrowth. Any axonal injury also triggers a vicious cycle of apoptosis. Understanding these hurdles provides us with a rough framework to appreciate the essential steps to bring about optic nerve regeneration： enhancing neuronal survival, axon regeneration, remyelination and establishing functional synapses to the original neuronal targets. In this review article, we will go through current potential treatments for optic nerve regeneration, which includes neurotrophic factor provision, inflammatory stimulation, growth inhibition suppression, intracellular signaling modification and modeling of bridging substrates.

关 键 词：optic nerve regeneration axonal regeneration neurotrophic factor inflammatory stimulation nerve bridging substances 

分 类 号：R338[医药卫生—人体生理学]