布地奈德雾化吸入治疗新生儿呼吸机相关性肺炎临床疗效观察  

Clinical effect of nebulized budesonide in treatment of neonatal ventilator-associated pneumonia

作　　者：王婷[1] 王佐[1] 范莉莉[1] 

机构地区：[1]安徽省芜湖市第一人民医院儿科,241000

出　　处：《淮海医药》2016年第1期23-25,共3页Journal of Huaihai Medicine

基　　金：安徽省芜湖市科技计划资助项目(2012hm31)

摘　　要：目的:观察布地奈德雾化吸入治疗新生儿呼吸机相关性肺炎的临床指标变化。方法:选取2013年收治的28例新生儿呼吸机相关性肺炎的患儿为观察组,并从2012年收治呼吸机相关性肺炎但未使用布地奈德治疗的新生儿中随机选取28例作为对照组。观察组在常规治疗基础上加用布地奈德悬液雾化吸入。观察2组患儿的机械通气时间、胸部X线检查好转时间、氧和指数、住院时间。2组患儿治愈出院后均追踪随访6个月,比较其头围、身长、体重等变化情况。结果:观察组患儿机械通气时间、胸部X线检查好转时间、住院时间均短与对照组患儿,差异有统计学意义(P<0.05)。2组患儿治疗前氧合指数比较差异无显著性(P>0.05),经治疗7 d后观察组患儿氧合指数提升明显高于对照组患儿,差异有统计学意义(P<0.05)。2组治愈患儿出院后随访半年,观察组男性患儿与女性患儿的头围、身长、体重在第3月、第6月时与对照组同性别比较,差异无统计学意义(P>0.05)。结论:在新生儿呼吸机相关性肺炎治疗中,雾化吸入布地奈德能有效缩短患儿机械通气时间、胸部X线好转时间、住院时间,改善其肺弥散功能,不影响患儿后期生长发育。Objective： To observe the clinical indicators of neonatal ventilator-associated pneumonia（ VAP） treated with oxygendriven budesonide nebulization. Methods： 28 neonates with VAP admitted in 2013 were randomly selected as an observation group. Another 28 neonates with VAP admitted in 2012 that did not use budesonide were chosen as a control group. The observation group was treated with the nebulization inhalation of budesonide based on the routine treatment. The time for mechanical ventilation,radiological clearance of chest X-ray images,oxygenation index,and hospitalization were observed and compared between the two groups. Children who were cured from the two groups were followed up for 6 months and their head circumference,body length and weight changes were compared. Data were analyzed by SPSS 19 software. Results： The time for mechanical ventilation,radiological clearance of chest X-ray images and duration of hospital stay of the observation group were significantly shortened compared with the control group（ P〈0. 05）.There was no significant difference on oxygenation index between the two groups（ P〈0. 05） before treatment. 7 days after treatment,the oxygenation index in the observation group was higher than that in the control group. There was no statistically significant difference（ P〈0. 05） in terms of the head circumference,body length,and body weight between the two groups in the first 3 months and first 6months after treatment. Conclusion： In the treatment of neonatal ventilator-associated pneumonia,oxygen-driven budesonide nebulization can shorten the time for mechanical ventilation,radiological clearance of chest X-ray images and duration of hospital stay. It can also improve the pulmonary diffusion function of children. It doesn＇t affect children＇s growth and development.

关 键 词：呼吸机相关性肺炎 布地奈德 雾化吸入 新生儿 

分 类 号：R563.1[医药卫生—呼吸系统]