河南省HIV感染长期不进展者及病毒控制者病例特征分析  

Characteristics of long-term non-progressors and HIV controllers among HIV-infections in Henan, China

作　　者：刘佳[1] 樊盼英[1] 薛秀娟[1] 孙定勇[1] 孙国清[1] 刘春华[1] 田随安[1] 李宁[1] 朱谦[1] 王哲[1] 

机构地区：[1]河南省疾病预防控制中心性病艾滋病防治研究所,郑州450016

出　　处：《中华流行病学杂志》2016年第2期227-231,共5页Chinese Journal of Epidemiology

基　　金：河南省医学科技攻关计划项目（201404045）;河南省重点科技攻关计划项目（142102310076）;国家科技重大专项（2012ZX10004905-001-003）;河南省医学科技攻关计划项目（2011010016）

摘　　要：目的 调查河南省HIV感染者中长期不进展者（LTNP）和病毒控制者（HC）存在情况及其病例特征。方法 利用我国艾滋病综合防治数据信息管理系统和河南省艾滋病检测实验室数据应用平台中的病例信息,及实验室检测结果判定HC和LTNP,并进行调查核实、样本采集和相关检测。结果 148例LTNP和HC中共随访到71例,其中LTNP有58例,HC有22例,同时是LTNP和HC有12例,仅是LTNP有46例,仅是HC有10例;男性50例（70.4%）;≥40岁有55例（77.5%）;均为汉族;职业为农民61例（85.9%）;感染途径为既往有偿供血52例（73.2%）;抗-HCV阳性56例（78.9%）;CD4＋T淋巴细胞计数均值（四分位数）538（445～654） cell/μl,病毒载量的对数均值（四分位数）为3.14（2.03～3.82） log10 copies/ml。HC的病毒载量对数均值低于LTNP（P=0.001）。结论 河南省HIV感染者中LTNP和HC的病例特征显著,更精确的分类有助于下一步研究。Objective To study the prevalence and characteristics of long-term non-progressors（LTNPs） and HIV controllers（HCs） among HIV-infections in Henan, China.Methods Data in two databases（Information management system of HIV/AIDS prevention and control;HIV/AIDS testing application platform of Henan） were used to identify the LTNPs and HCs, investigation and verification, sample collection and correlation testing were carried out thereafter.Results A total of 148 LTNPs/HCs were identified.Among them, 71 were followed up, including 58 LTNPs and 22 HCs, 12 cases were both LTNP and HC, 46 cases were LTNP but non-HC（LTNP＋HC-）, 10 cases of HC but non-LTNP.Of the 71 individuals, 50（70.4%） were males, 55（77.5%） were older than 40 years of age, all belonged to Han nationality, 61（85.9%） were farmers, 52（73.2%） were infected through former plasma donation, 56（78.9%） were-HCV positive.Median（interquartile range） of the CD4 counts was 538（445-654） cell/μl and with virus load as 3.14（2.03-3.82） log10 copies/ml.The median viral load of HC was lower than that of LTNP＋HC-（P=0.001）.Conclusion The characteristic of LTNPs and HCs in Henan HIV-infections were remarkable, more accurate classification of these cases was helpful to further research.

关 键 词：艾滋病病毒感染者 长期不进展者 病毒控制者 病例特征 

分 类 号：R512.91[医药卫生—内科学]