D-最优混料设计优选五味金色分散片制剂处方  

Optimization of formulations of Wuwei Jinse Dispersible Tablets using D-optimal mixture design

作　　者：关志宇[1] 吴文婷[1] 刘亚丽[1] 陈丽华[1] 格桑顿珠[2] 朱继孝[1] 罗晶[1] 尼玛次仁[2] 

机构地区：[1]江西中医药大学药学院,江西南昌330004 [2]西藏藏医学院,西藏拉萨850000

出　　处：《中国医院药学杂志》2016年第2期90-93,共4页Chinese Journal of Hospital Pharmacy

基　　金：江西民族传统药现代科技与产业发展协同创新项目(编号:JXXT201403018);江西省卫生计生委中医药科研项目(编号:2015A045);江西省高等学校教学改革研究项目(编号:JXJG-12-9-9);江西中医药大学开放性设计性实验项目(2015年)

摘　　要：目的:应用D-最优混料设计优选五味金色分散片处方。方法:以片剂外观、片剂硬度和崩解分散均匀时间的综合评分为指标,考察微晶纤维素、预胶化淀粉、交联羧甲基纤维素钠的配比对片剂成型的影响,并测定了优化处方片剂释放度。结果:微晶纤维素、预胶化淀粉和交联羧甲基纤维素钠的最优处方配比为23.27%∶19.36%∶7.37%;释放速度高于胶囊剂。结论:优化处方具有良好的分散片制剂学特定,重复性好;D-最优混料设计用于分散片处方优化效果较佳。OBJECTIVE To optimize formulations of Wuwei Jinse Dispersible Tablets using D-optimal mixture design. METHODS Composite score of appearance, hardness and dispersion uniformity time were used as indexes, D-optimal mixture design was adopted to investigate influences of microcrystalline cellulose, pregelatinized starch and croscarmellose sodium in op- timizing the formulation. RESULTS Study results showed that optimized proportion was mierocrystalline cellulose ： pregelati- nized starch ： croscarmellose sodium of 23.27%：19. 36%：7. 37%. The release speed was higher than capsules. CONCLUSION The optimized pharmaceutical formulation is feasible and stable for industrial production of Wuwei Jinse Dispersible Tablets. D-optimal mixture design is fit for formulation optimization of dispersible tablets.

关 键 词：五味金色丸 分散片 处方优化 D-最优混料设计 

分 类 号：R943[医药卫生—药剂学]