复方龙血竭巴布剂体外释放和透皮吸收的研究  

Study on drug release and in vitro transdermal absorption rate of Fufang Longxuejie Cataplasms

作　　者：李争艳[1] 袁小淋 张荣平[2] 余晓玲[1] 李月亭[3] 

机构地区：[1]昆明市中医医院,云南昆明650051 [2]昆明医科大学,云南昆明650500 [3]云南中医学院,云南昆明650200

出　　处：《中国医院药学杂志》2016年第2期94-96,共3页Chinese Journal of Hospital Pharmacy

基　　金：云南省应用基础研究计划项目(编号:2011FZ300)

摘　　要：目的：测定复方龙血竭巴布剂中龙血素A、龙血素B体外释放度及离体大鼠透皮吸收率。方法：通过测定龙血素A、龙血素B含量进行体外释放度和透皮吸收的试验,以HPLC法测定不同时间点龙血素A、龙血素B的累计释放量和累计透过量。结果：龙血素A、龙血素B分别在0.151~3.02μg和0.406~8.12μg范围内线性良好,龙血素A平均回收率为97.00%,RSD为1.99%,龙血素B平均回收率为97.60%,RSD为1.98%,龙血素A、龙血素B在2 h的释放度分别为94.53%、90.27%,透过立体大鼠皮肤72 h的透皮率分别为35.01%,44.60%。结论：复方龙血竭巴布剂具有良好的释放度和透皮性能。OBJECTIVE To determine release and in vitro transdermal absorption rate of loureirin A and loureirin B in fu- fang longxuejie cataplasms. METHODS Contents of loureirin A and loureirin B were measured to study on drug release and in vitro transdermal absorption rate. HPLC was applied to determine grand total of drug release and in vitro transdermal absorp- tion rate of loureirin A and loureirin B at different time points. RESULTS Loureirin A showed a good linearity in range of 0. 151 - 3.02μg, and loureirin B in range of 0. 406 - 8. 12μg, their average recovery rates were 97. 00% and 94. 53%, respec- tively. Release rates of loureirin A and B were 94. 530/00 and 90. 27% at 2h. Skin permeation rates of loureirin A and B were 35. 01% and 44. 60% at 72 h, respectively. CONCLUSION Fufang longxuejie cataplasms have good drug release and transder- mal absorption profiles.

关 键 词：巴布剂 龙血素A、B 体外释放度 体外透皮 

分 类 号：R927[医药卫生—药学]