由166例中药不良反应/事件报告分析看中药安全用药  

Safe medication of traditional Chinese medicine based on 166 reports of adverse drug reactions/adverse drug events

作　　者：潘莹[1] 刘韬[1] 梁蔚婷[1] 魏雪[1] 李晓燕[1] 黄红兵[1] 

机构地区：[1]华南肿瘤学国家重点实验室,肿瘤医学协同创新中心,中山大学肿瘤防治中心,广东广州510060

出　　处：《中国医院药学杂志》2016年第2期145-148,共4页Chinese Journal of Hospital Pharmacy

基　　金：广东省医院药学基金(编号:2012G28);广东省自然科学基金课题(编号:10451008901004256)

摘　　要：目的:通过对中药不良反应/事件(ADR/ADE)发生情况、特点及相关因素进行分析,为临床安全使用中药提供数据。方法:收集某院10年中药不良反应报告166例,采用回顾性研究方法从患者、ADR/ADE类别、涉及药品及合理用药等方面进行统计分析。结果:166例报告中66.3%ADR/ADE临床表现未被载入药品说明书;所涉中药98.2%为注射剂型,复方制剂ADR/ADE发生比例高于单方;51.2%的ADR/ADE涉及不合理用药,其中最常见的不合理使用情况为超剂量用药(30.7%)。结论:静脉用药、复方制剂以及不合理用药等因素增加中药ADR/ADE风险,临床使用时应注意用药监护。OBJECTIVE To analyze occurrence, characteristics and related factors of 166 cases of ADR/ADE, and provide data for safe medication of traditional Chinese medicine. METHODS A total of 166 cases of ADR/ADE associated with tradi- tional Chinese medicine were collected in Sun Yat-sen University Cancer Center （SYSUCC） from January 2005 to December 2014. Patient and drug characteristics, ADR/ADE type and medical orders of the cases were analyzed using retrospective study method. RESULTS Of 166 cases of ADRs/ADEs, new-onset cases accounted for 66. 3% injection formulation accounted for 98. 2~, compound formula had the higher incidence of ADRs/ADEs. Furthermore, inappropriate prescription was involved in 51.2% cases, and drug overdose （30. 7%） was the most common. CONCLUSION Risk of ADR/ADE associated with tradi- tional Chinese medicines is correlated with multiple factors, and pharmaceutical care should be applied to ensure safe medication of traditional Chinese medicines.

关 键 词：药品不良反应 药品不良事件 中药 安全用药 

分 类 号：R286[医药卫生—中药学]