太原地区急性呼吸道人偏肺病毒和人博卡病毒感染患儿临床特征分析  

Clinical features of human metapneumovirus and human bocavirus infections among children with acute respiratory tract infections in Taiyuan

作　　者：张云宏[1] 孙宇[2] 贾云霞[3] 刘燕[3] 兰涛[3] 赵林清[2] 钱渊[2] 朱汝南[2] 王乃昌[4] 

机构地区：[1]山西医科大学,山西太原030001 [2]首都儿科研究所病毒研究室,北京100020 [3]山西医科大学附属人民医院儿科,山西太原030012 [4]山西省疾病预防控制中心病毒研究室,山西太原030012

出　　处：《临床儿科杂志》2016年第2期93-96,共4页Journal of Clinical Pediatrics

摘　　要：目的了解太原地区急性呼吸道感染(ARTIs)儿童人偏肺病毒(hMPV)与人博卡病毒(HBoV)的感染情况及其临床和流行病学特征。方法采集2012年11月—2013年5月及2013年11月—2014年5月就诊的ARTIs患儿549例,采集咽拭子标本,应用实时PCR方法检测hMPV与HBoV。结果 549例患儿的咽拭子标本中hMPV阳性56例(10.2%),HBoV阳性15例(2.7%)。其中2012年11月—2013年5月hMPV与HBoV检出率分别为12.3%和2.0%,2013年11月—2014年5月hMPV与HBoV检出率分别为6.5%和4.0%,两时间段hMPV检出率差异有统计学意义(P<0.05),HBoV检出率差异无统计学意义(P>0.05);不同月份hMPV、HBoV检出率差异无统计学意义(P>0.05)。hMPV与HBoV均在<2岁组中检出率最高。hMPV在喘息性支气管炎与毛细支气管炎患儿中检出率最高。结论太原地区hMPV和HBoV与部分儿童尤其是婴幼儿ARTIs有关,hMPV是诱发部分婴幼儿喘息性疾病的重要病原体之一。Objective To investigate the status and clinical and epidemiological characteristics of human metapneumovirus（hMPV） and human bocavirus（HBoV） infections in children with acute respiratory tract infections（ARTIs） in Taiyuan.Methods A total of 549 children with ARTIs from November 2012 to May 2013 and November 2013 to May 2014 were recruited.The pharyngeal swab specimens were collected.The hMPV and HBoV were detected by using real-time PCR.Results In 549 children,56 children（10.2%） were hMPV positive on swab specimens,15 children（2.7%） were HBoV positive on swab specimens.The detection rates of hMPV and HBoV in November 2012 to May 2013 were 12.3% and 2.0%,respectively,and in November 2013 to May 2014 were 6.5% and 4.0%,respectively.The detection rate of hMPV was significantly different between two periods（P〈0.05）,while the detection rate of HBoV has no significant difference between two periods.In different months,the detection rate of hMPV and HBoV showed no significant difference.The highest detection rates of hMPV and HBoV were all in children younger than two years old.The highest detection rate of hMPV was in children with asthmatic bronchitis or bronchiolitis.Conclusion In Taiyuan,during the monitoring periods,the ARITS are associated with childhood hMPV and HBoV infection especially in infants and toddlers.hMPV is one of the most important pathogens in infants and toddlers with wheezing.

关 键 词：人偏肺病毒 人博卡病毒 呼吸道感染 儿童 

分 类 号：R725.1[医药卫生—儿科]