三七总皂苷抗缺血再灌注损伤机制研究进展  

Review on Mechanisms of Panax Notoginseng Saponins Against Ischemia-Reperfusion Injury

作　　者：姜丽[1] 宁可[1] 包怡敏[1] 

机构地区：[1]上海中医药大学生理教研室,上海200120

出　　处：《中华中医药学刊》2016年第2期267-270,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81303256;81202945)

摘　　要：三七总皂苷(panax notoginseng saponins PNS)是中药三七主要有效活性成分,具有抗缺血再灌注(ischemia-reperfusion injury I/R)损伤作用。近年研究表明主要通过抑制炎症反应、抗氧化应激、阻滞细胞内钙超载、改善能量代谢、减少细胞凋亡等途径保护组织器官再灌注损伤。现对三七总皂苷的具体成分、抗I/R损伤作用机制进行系统的总结和综述。Panax notoginseng saponins（ PNS）,the theactive ingredients of Chinese traditional medicine Panax notoginseng,can against ischemia reperfusion（ I / R） injury. In recent years,studies show that the mechanisms include inhibiting the inflammatory response,resisting to oxidative stress,blocking intracellular calcium overload,improving energy metabolism and reducing the apoptosis to protect organs from reperfusion injury. This paper summarized the mechanisms of Panax notoginseng saponins against ischemia-reperfusion injury.

关 键 词：三七总皂苷 缺血再灌注损伤 研究进展 

分 类 号：R284.3[医药卫生—中药学]