改善中药口服生物利用度的制剂技术研究进展  

Research Progress on Oral Bioavailability of Traditional Chinese Medicine Preparation

作　　者：李明玥[1] 倪健[1] 尹兴斌[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中华中医药学刊》2016年第2期307-311,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81173563);国家"重大新药创制"科技重大专项项目(2012ZX09103201-026);北京中医药大学协同创新项目(2013-XTCX-03)

摘　　要：近年来,社会对中药制剂的有效性越来越关注,但很多中药成分的口服生物利用度较低,如何改善这种情况是当前中药药剂学研究的重要任务。在查阅历年相关文献资料的基础上,从环糊精包合技术、自乳化技术、固体分散技术、磷脂复合物、纳米技术这5个技术展开,介绍每个技术的特点、提高生物利用度的原理,最后列举了近年来该技术用于中药口服生物利用度的具体研究实例。Recently,people pay more attention to the availability of traditional Chinese medicine preparation. However,the oral bioavailability of most Chinese native medicine ingredients is a bit low. How to improve this condition is a significant study of morden Chinese pharmacy. Based on relevant literature over the years,including Cyclodextrin inclusion technology,self-emulsifying technology,solid dispersion technology,phospholipid complexes and nano-technology,the article described the characteristics of each technology and its principle of improving the bioavailability and also cited specific examples of recent studies that the technology is used to improve the oral bioavailability of traditional Chinese medicine.

关 键 词：口服生物利用度 环糊精包合技术 自乳化技术 固体分散技术 磷脂复合技术 纳米技术 

分 类 号：R284.1[医药卫生—中药学]