广西巴马地区壮族家系白细胞端粒长度遗传模式  

The mode of inheritance of leukocyte telomere length in Guangxi Bama Zhuang long-lived families

作　　者：吴华裕[1] 罗晓秋[2] 罗桓[2] 彭均华[2] 刘承武[2] 尹瑞兴[3] 吕泽平 潘尚领[2] 

机构地区：[1]广西医科大学细胞生物学与遗传学教研室,广西南宁530021 [2]广西医科大学病理生理学教研室 [3]广西医科大学心血管研究所 [4]国家康复辅具研究中心附属康复医院神经内科

出　　处：《中国老年学杂志》2016年第4期769-771,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助项目(No.30860126;81360066)

摘　　要：目的探讨广西巴马地区壮族家系血液白细胞端粒长度的遗传模式。方法应用real-time PCR方法测定广西巴马地区壮族家系外周血白细胞相对端粒长度(LTL),并进行家系内子代LTL与其父代LTL的相关性分析。结果 (1)LTL随年龄增大而缩短,即与年龄呈负相关性;(2)子代群体中,女性LTL明显长于男性(P<0.05);(3)家系中第二代即子代LTL同时呈现母系和父系遗传模式。结论广西巴马地区壮族家系子代LTL明显受亲代LTL的影响,呈现明显的母系及父系遗传模式。Objective To explore the mode of inheritance of leukocyte telomere length（ LTL） for Zhuang long-lived families residing in Guangxi Bama area. Methods Relative LTL was determined by real- time PCR for members from Guangxi Bama Zhuang long-lived families,and the correlation of LTL between two generations in families was analyzed. Results（ 1） An inverse relationship was found between the LTL and age in all cohorts studied,i. e. LTL shortens with increasing age.（ 2） In offspring,females displayed significant longer mean LTL than males（ P〈0. 05）.（ 3） Offspring＇s LTL was inherited both maternally and paternally. Conclusions The offspring＇ s LTL is highly influenced by parental LTL in Guangxi Bama Zhuang long- lived families,which displays both maternal and paternal inheritance mode.

关 键 词：白细胞端粒长度 遗传模式 

分 类 号：R339.36[医药卫生—人体生理学]