三联疗法对糖尿病下肢血管病变患者踝肱指数和血流动力学的影响  

Influence of triple therapy on ankle brachial index and blood flow dynamics in patients with diabetic lower extremity arterial disease

作　　者：陈焱[1] 

机构地区：[1]河南省中医院,河南郑州450002

出　　处：《中国老年学杂志》2016年第4期826-828,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金青年基金项目(81001645)

摘　　要：目的观察前列地尔、血塞通和中药足疗三联疗法对糖尿病(DM)下肢血管病变患者踝肱指数和血流动力学的影响。方法随机将2013年1月至2014年4月在该院治疗的64例糖尿病下肢血管病变患者分为2组,所有患者均给予常规的治疗方法(包括降糖、降压、抗血小板、饮食控制),另外给予前列地尔注射液治疗,在上述基础上,对照组采用口服血塞通软胶囊;观察组在对照组的基础上,采用中药泡脚,治疗6 w后,观察2组的疗效和踝肱指数ABI、血流动力学及不良反应情况。结果两组患者年龄、性别、DM病程、体重指数、吸烟及下肢病变部位等一般资料均无显著性差异(P>0.05)。观察组的总有效率为93.75%,对照组为90.63%,两组无显著差异(χ2=1.069,P=0.785)。治疗前,2组的ABI、足背动脉血流量均无明显差异(P>0.05);经过6 w治疗后,2组的ABI、足背动脉血流量均出现显著升高(P<0.05);观察组治疗后的ABI、足背动脉血流量均高于对照组(P<0.05)。治疗前,2组的血流动力学指标均无明显差异(P>0.05);经过6 w治疗后,2组的血流动力学指标均出现显著下降(P<0.05);两组治疗后的ESR、EEP无明显差异(P>0.05),而观察组治疗后的全血黏度(ηb)、血浆黏度(ηp)、纤维蛋白原(Fib)均明显小于对照组(P<0.05)。两组不良反应发生情况无显著差异(P>0.05)。结论前列地尔、血塞通和中药足疗联合治疗糖尿病下肢血管病变疗效较好,能有效抑制动脉硬化,改善血流动力学情况。Objective To observe the influence of triple therapy on ankle brachial index（ ABI） and blood flow dynamics in patients with diabetic lower extremity arterial disease. Methods 64 patients with diabetic lower extremity arterial disease were divided into two groups. All patients were given conventional treatment including hypoglycemic,step-down,antiplatelet,diet control and Alprostadil fat emulsiom injection. On the basis of the above,32 cases in control group were given orally Xuesaitong soft capsule; on the basis of control group,patients in the observation group were used traditional Chinese medicine to soak the foot. After treatment for 6 weeks,the curative effect,ABI,blood flow dynamics and inflammation of the two groups were observed. Results Age,sex,duration of DM,body mass index,smoking and so on between two groups had no significant differences（ P〉0. 05）. The total effective rate of observation group was 93. 75%,which had no significant difference with that of control group（ 90. 63%,χ2= 1. 069,P = 0. 785）. Before the treatment,ABI,dorsalis pedis artery blood flow of two groups had no obvious difference（ P〉0. 05）. After treatment for six weeks,ABI,dorsalis pedis artery blood flow of two groups were significantly increased（ P〉0. 05）; ABI,dorsalis pedis artery blood flow after treatment in observation group were higher than those of control group（ P〈0. 05）. Before the treatment,hemodynamic indexes of two groups had no obvious difference（ P〈0. 05）. After treatment for six weeks,hemodynamic parameters in the two groups were reduced significantly（ P〈0. 05）; ESR,EEP after treatment between two groups had no significant difference（ P〉0. 05）,while ηP,ηb and Fib after treatment in observation group were significantly less than those of control group（ P〈0. 05）. There was no significant statistical significance in adverse reaction between two groups（ P〉0. 05）. Conclusions The curative effect of alprostadil,Xuesaitong and traditional Chinese medicine pedic

关 键 词：糖尿病 下肢血管病变 踝肱指数 血流动力学 

分 类 号：R587.1[医药卫生—内分泌]